{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang H"],"funding":["345 Talent Project of Shengjing Hospital of China Medical University","Scientific Research Project of the Liaoning Province Education Department","Natural Science Foundation of Liaoning Province","Young Elite Scientists Sponsorship Program by China Association for Science and Technology","Liaoning Revitalization Talents Program","JieBangGuaShuai Project of Liaoning Province"],"pagination":["66"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11221134"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["Background
Evidence has shown that the individual metrics in Life's Essential 8 (LE8), an updated cardiovascular health (CVH) concept proposed by the American Heart Association, play a role in the development of inflammatory bowel disease (IBD). However, epidemiological evidence on the overall LE8 on IBD risk remains limited. We aimed to assess the longitudinal associations of LE8-defined CVH and the risks of IBD and its subtypes, ulcerative colitis (UC) and Crohn's disease (CD). We also tested whether genetic susceptibility could modify these associations.Methods
A total of 260,836 participants from the UK Biobank were included. LE8 scores were determined by 8 metrics (physical activity, diet, nicotine exposure, sleep, body mass index, blood pressure, blood glucose, and bl"],"journal":["The international journal of behavioral nutrition and physical activity"],"pubmed_title":["Life's essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study."],"pmcid":["PMC11221134"],"funding_grant_id":["LJKMZ20221149","XLYC2203168","M0294","2020QNRC001","2020-MS-184","2021JH1/1040050"],"pubmed_authors":["Yang H","Xia Y","Ji C","Chang Q","Chen L","Ma Z","Zheng G","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Life's essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study.","description":"Background
Evidence has shown that the individual metrics in Life's Essential 8 (LE8), an updated cardiovascular health (CVH) concept proposed by the American Heart Association, play a role in the development of inflammatory bowel disease (IBD). However, epidemiological evidence on the overall LE8 on IBD risk remains limited. We aimed to assess the longitudinal associations of LE8-defined CVH and the risks of IBD and its subtypes, ulcerative colitis (UC) and Crohn's disease (CD). We also tested whether genetic susceptibility could modify these associations.Methods
A total of 260,836 participants from the UK Biobank were included. LE8 scores were determined by 8 metrics (physical activity, diet, nicotine exposure, sleep, body mass index, blood pressure, blood glucose, and bl","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-04T12:55:00.044Z","creation":"2025-04-04T12:55:00.044Z"},"accession":"S-EPMC11221134","cross_references":{"pubmed":["38956566"],"doi":["10.1186/s12966-024-01617-3"]}}