biostudies-literatureYang H345 Talent Project of Shengjing Hospital of China Medical UniversityScientific Research Project of the Liaoning Province Education DepartmentNatural Science Foundation of Liaoning ProvinceYoung Elite Scientists Sponsorship Program by China Association for Science and TechnologyLiaoning Revitalization Talents ProgramJieBangGuaShuai Project of Liaoning Province66https://www.ebi.ac.uk/biostudies/studies/S-EPMC11221134biostudies-literatureUnknown21(1)<h4>Background</h4>Evidence has shown that the individual metrics in Life's Essential 8 (LE8), an updated cardiovascular health (CVH) concept proposed by the American Heart Association, play a role in the development of inflammatory bowel disease (IBD). However, epidemiological evidence on the overall LE8 on IBD risk remains limited. We aimed to assess the longitudinal associations of LE8-defined CVH and the risks of IBD and its subtypes, ulcerative colitis (UC) and Crohn's disease (CD). We also tested whether genetic susceptibility could modify these associations.<h4>Methods</h4>A total of 260,836 participants from the UK Biobank were included. LE8 scores were determined by 8 metrics (physical activity, diet, nicotine exposure, sleep, body mass index, blood pressure, blood glucose, and blThe international journal of behavioral nutrition and physical activityLife's essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study.PMC11221134LJKMZ20221149XLYC2203168M02942020QNRC0012020-MS-1842021JH1/1040050Yang HXia YJi CChang QChen LMa ZZheng GZhao YfalseLife's essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study.<h4>Background</h4>Evidence has shown that the individual metrics in Life's Essential 8 (LE8), an updated cardiovascular health (CVH) concept proposed by the American Heart Association, play a role in the development of inflammatory bowel disease (IBD). However, epidemiological evidence on the overall LE8 on IBD risk remains limited. We aimed to assess the longitudinal associations of LE8-defined CVH and the risks of IBD and its subtypes, ulcerative colitis (UC) and Crohn's disease (CD). We also tested whether genetic susceptibility could modify these associations.<h4>Methods</h4>A total of 260,836 participants from the UK Biobank were included. LE8 scores were determined by 8 metrics (physical activity, diet, nicotine exposure, sleep, body mass index, blood pressure, blood glucose, and bl2024-01-01T00:00:00Z2024 Jul2025-04-04T12:55:00.044Z2025-04-04T12:55:00.044ZS-EPMC112211343895656610.1186/s12966-024-01617-3