biostudies-literatureKhojah ANCATS NIH HHSNIAMS NIH HHS20-25https://www.ebi.ac.uk/biostudies/studies/S-EPMC11221785biostudies-literatureUnknown5This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ <i>T</i> cells (>7 %) were observed in 19 % of untreated cases. Post-treatment, mean HLA-DR+ <i>T</i> cells decreased from 5.1 to 2.9 (<i>P</i> < 0.001), and serum neopterin levels declined from 19.3 to 9.1 nmol/L (<i>P</i> < 0.0001). A positive correlation between serum neopterin and HLA-DR T cell percentage was observed (<i>r</i> = 0.39, <i>P</i> = 0.01). Intravenous steroid treatment exhibited a 47.4 % improvement in HLA-DR+ <i>T</i> cells and a 50.5 % reduction in serum neopterin levels, in contrast to 14.8 % and 34.1 % in the oral steroid group. In conclClinical immunology communicationsIncreased percentage of HLA-DR T cells in untreated juvenile dermatomyositis.PMC11221785UL1 TR001422R21 AR077565Khanolkar ASchutt MBensen NMorgan GBukhari APachman LMKhojah AfalseIncreased percentage of HLA-DR T cells in untreated juvenile dermatomyositis.This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ <i>T</i> cells (>7 %) were observed in 19 % of untreated cases. Post-treatment, mean HLA-DR+ <i>T</i> cells decreased from 5.1 to 2.9 (<i>P</i> < 0.001), and serum neopterin levels declined from 19.3 to 9.1 nmol/L (<i>P</i> < 0.0001). A positive correlation between serum neopterin and HLA-DR T cell percentage was observed (<i>r</i> = 0.39, <i>P</i> = 0.01). Intravenous steroid treatment exhibited a 47.4 % improvement in HLA-DR+ <i>T</i> cells and a 50.5 % reduction in serum neopterin levels, in contrast to 14.8 % and 34.1 % in the oral steroid group. In concl2024-01-01T00:00:00Z2024 Jun2025-04-04T12:53:49.777Z2025-04-04T12:53:49.777ZS-EPMC112217853896237610.1016/j.clicom.2024.02.002