{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tierney BT"],"funding":["NASA | Johnson Space Center (JSC)","NIAID NIH HHS","NIEHS NIH HHS","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)","NCI NIH HHS"],"pagination":["1661-1675"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11222149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(7)"],"pubmed_abstract":["Maintenance of astronaut health during spaceflight will require monitoring and potentially modulating their microbiomes. However, documenting microbial shifts during spaceflight has been difficult due to mission constraints that lead to limited sampling and profiling. Here we executed a six-month longitudinal study to quantify the high-resolution human microbiome response to three days in orbit for four individuals. Using paired metagenomics and metatranscriptomics alongside single-nuclei immune cell profiling, we characterized time-dependent, multikingdom microbiome changes across 750 samples and 10 body sites before, during and after spaceflight at eight timepoints. We found that most alterations were transient across body sites; for example, viruses increased in skin sites mostly during"],"journal":["Nature microbiology"],"pubmed_title":["Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight."],"pmcid":["PMC11222149"],"funding_grant_id":["R01 CA249054","R01 MH117406","NNX16AO69A","P30 CA045508","R01MH117406","R01 AI151059","R01 ES032638","NNX14AH50G"],"pubmed_authors":["Qiu J","Altomare A","Kim J","Dhir R","Scott RT","Tierney BT","Wiseman K","MacKay M","Najjar D","Afshin EE","Church GM","Boddicker AM","Readhead BP","Zhao J","Garcia Medina JS","Park J","Mason CE","Wain Hirschberg J","Gatt C","Kruglyak S","Beyaz S","Meydan C","Al-Ghalith GA","Brereton N","Lajoie BR","Kleinman AS","Overbey EG","Venkateswaran KJ","Bhattacharya C","Damle N","Ryon KA","Houerbi N","Levy S","Moreno J","Borg J","Sierra MA","Foox J"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight.","description":"Maintenance of astronaut health during spaceflight will require monitoring and potentially modulating their microbiomes. However, documenting microbial shifts during spaceflight has been difficult due to mission constraints that lead to limited sampling and profiling. Here we executed a six-month longitudinal study to quantify the high-resolution human microbiome response to three days in orbit for four individuals. Using paired metagenomics and metatranscriptomics alongside single-nuclei immune cell profiling, we characterized time-dependent, multikingdom microbiome changes across 750 samples and 10 body sites before, during and after spaceflight at eight timepoints. We found that most alterations were transient across body sites; for example, viruses increased in skin sites mostly during","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-01T20:34:30.08Z","creation":"2025-04-06T11:37:30.748Z"},"accession":"S-EPMC11222149","cross_references":{"pubmed":["38862604"],"doi":["10.1038/s41564-024-01635-8"]}}