{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hjelt A"],"funding":["Academy of Finland","Business Finland","Research Council of Finland","Victoriastiftelsen","Svenska Kulturfonden","InFLAMES Flagship Programme of the Academy of Finland","Novo Nordisk Fonden"],"pagination":["e1234"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11222167"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(4)"],"pubmed_abstract":["The association of hormonal contraception with increased risk of inflammatory bowel disease (IBD) observed in females suggests involvement of ovarian hormones, such as estradiol, and the estrogen receptors in the progression of intestinal inflammation. Here, we investigated the effects of prophylactic SERM2 and estradiol supplementation in dextran sulfate sodium-induced colitis using mice with intact ovaries and ovariectomized (OVX) female mice. We found that graded colitis score was threefold reduced in the OVX mice, compared to mice with intact ovaries. Estradiol supplementation, however, aggravated the colitis in OVX mice, increasing the colitis score to a similar level than what was observed in the intact mice. Further, we observed that immune infiltration and gene expression of inflam"],"journal":["Pharmacology research & perspectives"],"pubmed_title":["Estrogen deprivation and estrogen receptor α antagonism decrease DSS colitis in female mice."],"pmcid":["PMC11222167"],"funding_grant_id":["332582","315139","NNF21OC0068904","337531","20240472","253/31/2019","187699","473/31/2015","357911"],"pubmed_authors":["Al-Ramahi D","Anttila S","Toivola DM","Hjelt A","Rokka A","Maatta J","Wiklund A","Polari L"],"additional_accession":[]},"is_claimable":false,"name":"Estrogen deprivation and estrogen receptor α antagonism decrease DSS colitis in female mice.","description":"The association of hormonal contraception with increased risk of inflammatory bowel disease (IBD) observed in females suggests involvement of ovarian hormones, such as estradiol, and the estrogen receptors in the progression of intestinal inflammation. Here, we investigated the effects of prophylactic SERM2 and estradiol supplementation in dextran sulfate sodium-induced colitis using mice with intact ovaries and ovariectomized (OVX) female mice. We found that graded colitis score was threefold reduced in the OVX mice, compared to mice with intact ovaries. Estradiol supplementation, however, aggravated the colitis in OVX mice, increasing the colitis score to a similar level than what was observed in the intact mice. Further, we observed that immune infiltration and gene expression of inflam","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-18T13:50:38.963Z","creation":"2025-04-04T12:54:34.086Z"},"accession":"S-EPMC11222167","cross_references":{"pubmed":["38961539"],"doi":["10.1002/prp2.1234"]}}