biostudies-literatureUnknown11(7)Wright WF<h4>Background</h4>Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are syndromes commonly used as medical diagnoses. Since the existing literature has a mixture of diagnostic approaches, developing consensus-based recommendations would be helpful for clinicians, researchers, and patients.<h4>Methods</h4>A modified Delphi process was performed from October 2022 to July 2023, involving 4 rounds of online surveys and 2 live video conferences. The panel comprised international experts recruited based on peer-reviewed published publications and studies.<h4>Results</h4>Among 50 invited experts, 26 (52.0%) agreed to participate. Twenty-three panelists completed round 1 of the survey, 21 completed rounds 2 and 3, 20 completed round 4, and 7 participated in round 5 live videoOpen forum infectious diseasesofae298https://www.ebi.ac.uk/biostudies/studies/S-EPMC11222709biostudies-literatureRecommendations for Updating Fever and Inflammation of Unknown Origin From a Modified Delphi Consensus Panel.PMC11222709Rupali PInternational Fever and Inflammation of Unknown Origin Research Working GroupCarroll KPascal SWright WFBharucha TNaito TBetrains AVanderschueren SBaicus CBor DRowe SRovers CPAuwaerter PGTeruhiko TOyen WJBosilkovski MStelmash LYenilmez EMulders-Manders CMBrown MZenone TSaxinger LFusco FMHarris GfalseRecommendations for Updating Fever and Inflammation of Unknown Origin From a Modified Delphi Consensus Panel.<h4>Background</h4>Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are syndromes commonly used as medical diagnoses. Since the existing literature has a mixture of diagnostic approaches, developing consensus-based recommendations would be helpful for clinicians, researchers, and patients.<h4>Methods</h4>A modified Delphi process was performed from October 2022 to July 2023, involving 4 rounds of online surveys and 2 live video conferences. The panel comprised international experts recruited based on peer-reviewed published publications and studies.<h4>Results</h4>Among 50 invited experts, 26 (52.0%) agreed to participate. Twenty-three panelists completed round 1 of the survey, 21 completed rounds 2 and 3, 20 completed round 4, and 7 participated in round 5 live video2024-01-01T00:00:00Z2024 Jul2025-04-21T16:13:36.529Z2025-04-21T16:13:36.529ZS-EPMC112227093896684810.1093/ofid/ofae298