biostudies-literatureUnknown5(3)Ravi N<h4>Aim</h4>There is limited data on prognostic value of baseline plasma cell free DNA (cfDNA) in advanced squamous non-small cell lung cancer (sq-NSCLC). This prospective observational study aimed to assess change in plasma cfDNA levels in locally-advanced/metastatic sq-NSCLC with chemotherapy and its correlation with symptom-scores and radiological-responses.<h4>Methods</h4>Chemotherapy-naive patients with stages-IIIB/IIIC/IV sq-NSCLC (<i>n</i> = 59), smokers with chronic obstructive pulmonary disease [COPD, COPD-controls (CC); <i>n</i> = 27] and healthy-controls (<i>n</i> = 25) were enrolled. Respiratory symptom burden (RSB) and total symptom burden (TSB) were calculated from mean visual-analog-scores (VAS) of dyspnoea, cough, chest pain, hemoptysis RSB, anorexia and fatigue (all six foExploration of targeted anti-tumor therapy508-521https://www.ebi.ac.uk/biostudies/studies/S-EPMC11222716biostudies-literatureChemotherapy related changes in cfDNA levels in squamous non-small cell lung cancer: correlation with symptom scores and radiological responses.PMC11222716Bal APrasad KTSingh NGarg MKapoor RRavi NGupta PfalseChemotherapy related changes in cfDNA levels in squamous non-small cell lung cancer: correlation with symptom scores and radiological responses.<h4>Aim</h4>There is limited data on prognostic value of baseline plasma cell free DNA (cfDNA) in advanced squamous non-small cell lung cancer (sq-NSCLC). This prospective observational study aimed to assess change in plasma cfDNA levels in locally-advanced/metastatic sq-NSCLC with chemotherapy and its correlation with symptom-scores and radiological-responses.<h4>Methods</h4>Chemotherapy-naive patients with stages-IIIB/IIIC/IV sq-NSCLC (<i>n</i> = 59), smokers with chronic obstructive pulmonary disease [COPD, COPD-controls (CC); <i>n</i> = 27] and healthy-controls (<i>n</i> = 25) were enrolled. Respiratory symptom burden (RSB) and total symptom burden (TSB) were calculated from mean visual-analog-scores (VAS) of dyspnoea, cough, chest pain, hemoptysis RSB, anorexia and fatigue (all six fo2024-01-01T00:00:00Z20242025-04-04T19:23:06.268Z2025-04-04T19:23:06.268ZS-EPMC112227163896617310.37349/etat.2024.00232