biostudies-literatureRosmus DDStudienstiftung des Deutschen VolkesDeutsche ForschungsgemeinschaftBerta-Ottenstein-Program for Clinician Scientists, Faculty of Medicine, University of FreiburgUniversität AugsburgDeutsche Ophthalmologische Gesellschaft168https://www.ebi.ac.uk/biostudies/studies/S-EPMC11223341biostudies-literatureUnknown21(1)<h4>Background</h4>The eye is a highly specialized sensory organ which encompasses the retina as a part of the central nervous system, but also non-neural compartments such as the transparent vitreous body ensuring stability of the eye globe and a clear optical axis. Hyalocytes are the tissue-resident macrophages of the vitreous body and are considered to play pivotal roles in health and diseases of the vitreoretinal interface, such as proliferative vitreoretinopathy or diabetic retinopathy. However, in contrast to other ocular macrophages, their embryonic origin as well as the extent to which these myeloid cells might be replenished by circulating monocytes remains elusive.<h4>Results</h4>In this study, we combine transgenic reporter mice, embryonic and adult fate mapping approaches as weJournal of neuroinflammationRedefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body.PMC11223341507881424SFB/TRR167Kuhrt HLange CWieghofer PFroba JRosmus DDHansen SMMasuda TKoch JAjami BPrinz MArnhold FWolf JHausmann AGericke MKierdorf KBoneva SChiot AfalseRedefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body.<h4>Background</h4>The eye is a highly specialized sensory organ which encompasses the retina as a part of the central nervous system, but also non-neural compartments such as the transparent vitreous body ensuring stability of the eye globe and a clear optical axis. Hyalocytes are the tissue-resident macrophages of the vitreous body and are considered to play pivotal roles in health and diseases of the vitreoretinal interface, such as proliferative vitreoretinopathy or diabetic retinopathy. However, in contrast to other ocular macrophages, their embryonic origin as well as the extent to which these myeloid cells might be replenished by circulating monocytes remains elusive.<h4>Results</h4>In this study, we combine transgenic reporter mice, embryonic and adult fate mapping approaches as we2024-01-01T00:00:00Z2024 Jul2025-04-04T23:54:58.306Z2025-04-04T23:54:58.306ZS-EPMC112233413896149810.1186/s12974-024-03110-x