biostudies-literatureWang HGroup Research SchemeCollaborative Research Fund of University Grants CommitteeNational Natural Science Foundation of ChinaHealth and Medical Research Fund667https://www.ebi.ac.uk/biostudies/studies/S-EPMC11223378biostudies-literatureUnknown24(1)<h4>Background</h4>The available evidence presented inconsistencies and inconclusive findings regarding the associations between co-existing asthma and mortality among COVID-19 patients. The objective of the current study is to investigate the relationship between asthma and severe outcomes after SARS-CoV-2 Omicron infection in an infection-naïve population.<h4>Methods</h4>A retrospective cohort study using propensity score matching was conducted. The COVID-19 patients requiring hospitalisation in Hong Kong from January 1, 2022, to November 13, 2022, an Omicron-predominated period, were identified. Severe clinical outcomes were defined as ICU admission and inpatient death after the first positive PCR results as well as a composite outcome of both.<h4>Results</h4>Of the 74,396 hospitalised BMC infectious diseasesAssociation between asthma and COVID-19 severity during Omicron epidemic: a retrospective cohort study using real-world data.PMC1122337871974165C4139-20GCOVID190105Li CGuo ZChan KCCWang HYam CHKChong KCLi KWei YHung CTYeoh EKChow TYZhao SJiang XChan RWYWang ZLeung EYMfalseAssociation between asthma and COVID-19 severity during Omicron epidemic: a retrospective cohort study using real-world data.<h4>Background</h4>The available evidence presented inconsistencies and inconclusive findings regarding the associations between co-existing asthma and mortality among COVID-19 patients. The objective of the current study is to investigate the relationship between asthma and severe outcomes after SARS-CoV-2 Omicron infection in an infection-naïve population.<h4>Methods</h4>A retrospective cohort study using propensity score matching was conducted. The COVID-19 patients requiring hospitalisation in Hong Kong from January 1, 2022, to November 13, 2022, an Omicron-predominated period, were identified. Severe clinical outcomes were defined as ICU admission and inpatient death after the first positive PCR results as well as a composite outcome of both.<h4>Results</h4>Of the 74,396 hospitalised 2024-01-01T00:00:00Z2024 Jul2025-04-04T12:55:04.151Z2025-04-04T12:55:04.151ZS-EPMC112233783896135010.1186/s12879-024-09520-9