{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu Z"],"funding":["National Science Foundation of China","ShanghaiTech University","NIH HHS"],"pagination":["RP89903"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11223767"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Precise developmental timing control is essential for organism formation and function, but its mechanisms are unclear. In <i>C. elegans</i>, the microRNA <i>lin-4</i> critically regulates developmental timing by post-transcriptionally downregulating the larval-stage-fate controller LIN-14. However, the mechanisms triggering the activation of <i>lin-4</i> expression toward the end of the first larval stage remain unknown. We demonstrate that the transmembrane transcription factor MYRF-1 is necessary for <i>lin-4</i> activation. MYRF-1 is initially localized on the cell membrane, and its increased cleavage and nuclear accumulation coincide with <i>lin-4</i> expression timing. MYRF-1 regulates <i>lin-4</i> expression cell-autonomously and hyperactive MYRF-1 can prematurely drive <i>lin-4</i> "],"journal":["eLife"],"pubmed_title":["Essential function of transmembrane transcription factor MYRF in promoting transcription of miRNA <i>lin-4</i> during <i>C. elegans</i> development."],"pmcid":["PMC11223767"],"funding_grant_id":["31900397","P40 OD010440"],"pubmed_authors":["Qi YB","Wang Z","Xu Z","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Essential function of transmembrane transcription factor MYRF in promoting transcription of miRNA <i>lin-4</i> during <i>C. elegans</i> development.","description":"Precise developmental timing control is essential for organism formation and function, but its mechanisms are unclear. In <i>C. elegans</i>, the microRNA <i>lin-4</i> critically regulates developmental timing by post-transcriptionally downregulating the larval-stage-fate controller LIN-14. However, the mechanisms triggering the activation of <i>lin-4</i> expression toward the end of the first larval stage remain unknown. We demonstrate that the transmembrane transcription factor MYRF-1 is necessary for <i>lin-4</i> activation. MYRF-1 is initially localized on the cell membrane, and its increased cleavage and nuclear accumulation coincide with <i>lin-4</i> expression timing. MYRF-1 regulates <i>lin-4</i> expression cell-autonomously and hyperactive MYRF-1 can prematurely drive <i>lin-4</i> ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-04T23:54:35.716Z","creation":"2025-04-04T23:54:35.716Z"},"accession":"S-EPMC11223767","cross_references":{"pubmed":["38963411"],"doi":["10.7554/eLife.89903"]}}