biostudies-literatureGuo SNatural Science Foundation of Jiangxi ProvinceNatural Science Foundation of Jiangxi Province (Jiangxi Province Natural Science Foundation)National Natural Science Foundation of ChinaNational Natural Science Foundation of China (National Science Foundation of China)5628https://www.ebi.ac.uk/biostudies/studies/S-EPMC11224320biostudies-literatureUnknown15(1)The control of a molecule's geometry, chirality, and physical properties has long been a challenging pursuit. Our study introduces a dependable method for assembling D₃-symmetric trigonal bipyramidal coordination cages. Specifically, D_2h-symmetric anions, like oxalate and chloranilic anions, self-organize around a metal ion to form chiral-at-metal anionic complexes, which template the formation of D₃-symmetric trigonal bipyramidal coordination cages. The chirality of the trigonal bipyramid is determined by the point chirality of chiral amines used in forming the ligands. Additionally, these cages exhibit chiral selectivity for the included chiral-at-metal anionic template. Our method is broadly applicable to various ligand systems, enabling the constructionNature communicationsEnantiopure trigonal bipyramidal coordination cages templated by in situ self-organized D_2h-symmetric anions.PMC112243202207108322201075BK20211608Zhang DYang YZhan WWDuan YHGuo SYang FLZhou JfalseEnantiopure trigonal bipyramidal coordination cages templated by in situ self-organized D_2h-symmetric anions.The control of a molecule's geometry, chirality, and physical properties has long been a challenging pursuit. Our study introduces a dependable method for assembling D₃-symmetric trigonal bipyramidal coordination cages. Specifically, D_2h-symmetric anions, like oxalate and chloranilic anions, self-organize around a metal ion to form chiral-at-metal anionic complexes, which template the formation of D₃-symmetric trigonal bipyramidal coordination cages. The chirality of the trigonal bipyramid is determined by the point chirality of chiral amines used in forming the ligands. Additionally, these cages exhibit chiral selectivity for the included chiral-at-metal anionic template. Our method is broadly applicable to various ligand systems, enabling the construction2024-01-01T00:00:00Z2024 Jul2025-04-04T19:23:33.99Z2025-04-04T19:23:33.99ZS-EPMC112243203896521510.1038/s41467-024-49964-w