biostudies-literatureFOxTROT Collaborating GroupNational Institute for Health Research (NIHR)283-293https://www.ebi.ac.uk/biostudies/studies/S-EPMC11224564biostudies-literatureUnknown280(2)<h4>Objective</h4>This study aimed to identify risk criteria available before the point of treatment initiation that can be used to stratify the risk of obstruction in patients undergoing neoadjuvant chemotherapy (NAC) for high-risk colon cancer.<h4>Background</h4>Global implementation of NAC for colon cancer, informed by the FOxTROT trial, may increase the risk of bowel obstruction.<h4>Methods</h4>A case-control study, nested within an international randomized controlled trial (FOxTROT; ClinicalTrials.gov: NCT00647530). Patients with high-risk operable colon cancer (radiologically staged T3-4 N0-2 M0) that were randomized to NAC and developed large bowel obstruction were identified. First, clinical outcomes were compared between patients receiving NAC in FOxTROT who did and did not develoAnnals of surgeryRisk of Bowel Obstruction in Patients Undergoing Neoadjuvant Chemotherapy for High-risk Colon Cancer: A Nested Case-control-matched Analysis of an International, Multicenter, Randomized Controlled Trial (FOxTROT).PMC11224564NIHR200162NIHR300175Weerasinghe SWest NSusnerwala SZiprin PWest DWilcockson ASukumar SBurgess POstrowski JSeymour MGollins SSparrow GHartley JCast JLind PRosenkilde MSanders SLangman GYoung RTiam RPfeiffer PCorr CEscola CLLindh BJenkins RHandley KWhite DWong NKamposioras KGulati MWoodcock NNichols PBridgewater JYilmaz MPunia PMorton DHowitt CBeaumont EBurnett HBansal AMacklin CHigginson AFaux WMustajab ALaurberg SHolt GBiddlestone LMangalika SDevarajan GDunn WChatterjee MSaunders MGoh VParmar Chair MGlynne-Jones RMurray DDavenport AMikhaeel GSoomal RBrittenden JChakrabarty BEllis RGhiridaran SDe AKennedy GKulkarni RNelson CBusby KSaeed MMaskell GRadstone DAtkinson MKennedy RFarrugia DPlanner AGeh IMoorghen MConn ASnape SRamesh SMaw APhillips APeto Chair RHadaki MDundas SObichere AHansen FHansen TTarver DAgrawal SSeligman JOliver AHochhauser DSteward MBaxter ALamparelli MBranagan GMcAdam GGlaholm JKitsanta PBurn PPage ALake STaniere PAlkhaldi ALyons ALanaspre EGeraghty JMmeka WCook IDesai AFurniss DScholefield JBateman ACook SMelville DHarries SMaarouf ZDesai SMuzaffar SThomas MThomas TDent JKumaran GChiphang AChappell MGujral DMaisey NMitchell PTsang DRoberts COrme AMcPhail NHaselden JAgrawal NClarke ASherriff DDenson JMuthuramalingam SMiddleton GYates SLavin VOgunbiyi OWatson AAdie LSherwin ESingh RBarlow CCrosby TRea DArul DBathurst NFalk SPotter VMaleki KSoop MHickish TShiu KOlliff JKunene VTighe MCoxon FLittleford SAlexander JMayer ASlevin MBannister JGoldin RSteven NSephton MHarrison JWalker GLund JHendrickse CKrell DBeggs ABurling DSmith DKhan AShareef DSmith GAli NHinson FHarle AAli MWarren BSmith SNicoll JShatwell WCooper EKhan UChapman MWright PIlsley DFOxTROT Collaborating GroupWilliams NLord MJohn LCunningham DPai DTaylor SWilliams GTaylor PBeharry NBale CJames STaylor ACallaway MHall MBronder CJain SAbbott GWatkins JCoup AOrbell JMyint ASLaasch HMukhtar HHainsworth PO'Toole LAdab FHasan JRoy RGopalakrishnan KLast KGupta RGray ZGopal KKirby RGray RAnyamene NBlaquiere RKerwat RRichman PBlunt DTarapowewalla DKhaira MThompson AFozard BBraun MHamid BHamid ALancaster DNorthover JHampton JEld MGill TBorgstein RMehta SHill JLivingstone JGupta MPeters MScullion DGlasbey JDawson PDworkin MLeonard PAbgamu DHilman SVivekanandan SNeedham SScott DBeehen RPitt MScott NRadharkrishna GScott JFrancis NJensen KLott MAsmussen JMenon SMurakami KJackson ATolan DScott-Brown MAhlstrom HBritton IShablak AZaitoun AJackson SGutmann JSundaresan VPranesh NZeiderman MMoore PBell JO'Neil HSwift IEuinton HHayes SRodriguez-Justo MWadsley JWalsh CHughes MRaouf SO'Brien JLowndes SWilshaw VJadhav VTalbot RChandler IClenton SLofts FChong HBaijal SHornbuckle JDavies MWalkington LDewdney ALee SRooney NDay NEaton DAbdullah NFerry DCorrea PDalton SHopkins KAdams CDega RTekkis PHolland COrrell JO'Leary DLoveday EWilson DAdams RAmin SRooney PAhmad RHuang JSpendler KGLowdell CRees JRees CMomtahan NBrown GAhmad MBerry JKweka ELowe ABrady JDe Winton EPartridge WWotherspoon AOsborne RGlimelius BChurn MSil RGrumett SChurch RQaiyum MOsborne MSinha RCrabtree MIveson TSinha YChandran PKawesha AFinan PPallan AStenhouse GWalther JIsmail TCleator SKurien GCruickshank NRobinson JEason DDaniels IQuirke PDobson MMilosavljevic ZVimalachandran DPalmer AMagill LPalmer DMcBain CBrown JCampbell FMorgan SFord AMorgan MfalseRisk of Bowel Obstruction in Patients Undergoing Neoadjuvant Chemotherapy for High-risk Colon Cancer: A Nested Case-control-matched Analysis of an International, Multicenter, Randomized Controlled Trial (FOxTROT).<h4>Objective</h4>This study aimed to identify risk criteria available before the point of treatment initiation that can be used to stratify the risk of obstruction in patients undergoing neoadjuvant chemotherapy (NAC) for high-risk colon cancer.<h4>Background</h4>Global implementation of NAC for colon cancer, informed by the FOxTROT trial, may increase the risk of bowel obstruction.<h4>Methods</h4>A case-control study, nested within an international randomized controlled trial (FOxTROT; ClinicalTrials.gov: NCT00647530). Patients with high-risk operable colon cancer (radiologically staged T3-4 N0-2 M0) that were randomized to NAC and developed large bowel obstruction were identified. First, clinical outcomes were compared between patients receiving NAC in FOxTROT who did and did not develo2024-01-01T00:00:00Z2024 Aug2026-06-08T06:29:01.039Z2026-06-08T03:14:32.002ZS-EPMC112245643794714010.1097/SLA.0000000000006145