{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["280(2)"],"submitter":["Sperry JL"],"pubmed_abstract":["<h4>Objective</h4>To determine the feasibility, efficacy, and safety of early cold stored platelet transfusion compared with standard care resuscitation in patients with hemorrhagic shock.<h4>Background</h4>Data demonstrating the safety and efficacy of early cold stored platelet transfusion are lacking following severe injury.<h4>Methods</h4>A phase 2, multicenter, randomized, open label, clinical trial was performed at 5 US trauma centers. Injured patients at risk of large volume blood transfusion and the need for hemorrhage control procedures were enrolled and randomized. The intervention was the early transfusion of a single apheresis cold stored platelet unit, stored for up to 14 days versus standard care resuscitation. The primary outcome was feasibility and the principal clinical out"],"journal":["Annals of surgery"],"pagination":["212-221"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11224567"],"repository":["biostudies-literature"],"pubmed_title":["Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial."],"pmcid":["PMC11224567"],"pubmed_authors":["Inaba K","Mallett-Smith S","Cotton BA","Doherty JE","Spinella PC","Love ET","Wisniewski SR","Harner AM","Hoffman MK","Sperry JL","Kornblith LZ","Leeper CM","Rosario-Rivera BL","Kutcher ME","Yazer MH","Guyette FX","Bai Y","Vincent LE","Wilson CT","Cuschieri J","Kornblith AE","Seger CP","Cold Stored Platelet for Hemorrhagic Shock (CRISP-HS) Study Group","Fox EE","Zadorozny EV","Neal MD","Hudgins J"],"additional_accession":[]},"is_claimable":false,"name":"Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial.","description":"<h4>Objective</h4>To determine the feasibility, efficacy, and safety of early cold stored platelet transfusion compared with standard care resuscitation in patients with hemorrhagic shock.<h4>Background</h4>Data demonstrating the safety and efficacy of early cold stored platelet transfusion are lacking following severe injury.<h4>Methods</h4>A phase 2, multicenter, randomized, open label, clinical trial was performed at 5 US trauma centers. Injured patients at risk of large volume blood transfusion and the need for hemorrhage control procedures were enrolled and randomized. The intervention was the early transfusion of a single apheresis cold stored platelet unit, stored for up to 14 days versus standard care resuscitation. The primary outcome was feasibility and the principal clinical out","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-08T06:50:13.836Z","creation":"2026-06-08T03:14:31.793Z"},"accession":"S-EPMC11224567","cross_references":{"pubmed":["38708880"],"doi":["10.1097/SLA.0000000000006317"]}}