biostudies-literatureUnknown280(2)Sperry JL<h4>Objective</h4>To determine the feasibility, efficacy, and safety of early cold stored platelet transfusion compared with standard care resuscitation in patients with hemorrhagic shock.<h4>Background</h4>Data demonstrating the safety and efficacy of early cold stored platelet transfusion are lacking following severe injury.<h4>Methods</h4>A phase 2, multicenter, randomized, open label, clinical trial was performed at 5 US trauma centers. Injured patients at risk of large volume blood transfusion and the need for hemorrhage control procedures were enrolled and randomized. The intervention was the early transfusion of a single apheresis cold stored platelet unit, stored for up to 14 days versus standard care resuscitation. The primary outcome was feasibility and the principal clinical outAnnals of surgery212-221https://www.ebi.ac.uk/biostudies/studies/S-EPMC11224567biostudies-literatureEarly Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial.PMC11224567Inaba KMallett-Smith SCotton BADoherty JESpinella PCLove ETWisniewski SRHarner AMHoffman MKSperry JLKornblith LZLeeper CMRosario-Rivera BLKutcher MEYazer MHGuyette FXBai YVincent LEWilson CTCuschieri JKornblith AESeger CPCold Stored Platelet for Hemorrhagic Shock (CRISP-HS) Study GroupFox EEZadorozny EVNeal MDHudgins JfalseEarly Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial.<h4>Objective</h4>To determine the feasibility, efficacy, and safety of early cold stored platelet transfusion compared with standard care resuscitation in patients with hemorrhagic shock.<h4>Background</h4>Data demonstrating the safety and efficacy of early cold stored platelet transfusion are lacking following severe injury.<h4>Methods</h4>A phase 2, multicenter, randomized, open label, clinical trial was performed at 5 US trauma centers. Injured patients at risk of large volume blood transfusion and the need for hemorrhage control procedures were enrolled and randomized. The intervention was the early transfusion of a single apheresis cold stored platelet unit, stored for up to 14 days versus standard care resuscitation. The primary outcome was feasibility and the principal clinical out2024-01-01T00:00:00Z2024 Aug2026-06-08T06:50:13.836Z2026-06-08T03:14:31.793ZS-EPMC112245673870888010.1097/SLA.0000000000006317