biostudies-literatureCheng Hthe International Science and Technology Collaboration Projector of Xinjiang Production and Construction Corpsthe National Natural Science Foundation of China179https://www.ebi.ac.uk/biostudies/studies/S-EPMC11225290biostudies-literatureUnknown17(1)<h4>Background</h4>There is a high incidence of cervical cancer in Xinjiang. Genetic variation in human papillomavirus may increase its ability to invade, spread, and escape host immune response.<h4>Methods</h4>HPV16 genome was sequenced for 90 positive samples of HPV16 infection. Sequences of the E4, E5 and L2 genes were analysed to reveal sequence variation of HPV16 in Xinjiang and the distribution of variation among the positive samples of HPV16 infection.<h4>Results</h4>Eighty-one of the 90 samples of HPV16 infection showed variation in HPV16 E4 gene with 18 nucleotide variation sites, of which 8 sites were synonymous variations and 11 missense variations. 90 samples of HPV16 infection showed variation in HPV16 E5 and L2 genes with 16 nucleotide variation sites (6 synonymous, 11 missenBMC medical genomicsAnalysis of human papillomavirus type 16 E4, E5 and L2 gene variations among women with cervical infection in Xinjiang, China.PMC112252902019BC00782060518Li HPan ZDong YLi DZhe XShao RCheng HTuo JWang LZhao XfalseAnalysis of human papillomavirus type 16 E4, E5 and L2 gene variations among women with cervical infection in Xinjiang, China.<h4>Background</h4>There is a high incidence of cervical cancer in Xinjiang. Genetic variation in human papillomavirus may increase its ability to invade, spread, and escape host immune response.<h4>Methods</h4>HPV16 genome was sequenced for 90 positive samples of HPV16 infection. Sequences of the E4, E5 and L2 genes were analysed to reveal sequence variation of HPV16 in Xinjiang and the distribution of variation among the positive samples of HPV16 infection.<h4>Results</h4>Eighty-one of the 90 samples of HPV16 infection showed variation in HPV16 E4 gene with 18 nucleotide variation sites, of which 8 sites were synonymous variations and 11 missense variations. 90 samples of HPV16 infection showed variation in HPV16 E5 and L2 genes with 16 nucleotide variation sites (6 synonymous, 11 missen2024-01-01T00:00:00Z2024 Jul2026-06-02T21:18:19.859Z2025-04-04T12:21:27.094ZS-EPMC112252903896553810.1186/s12920-024-01926-3