{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pifer PM"],"funding":["NCI NIH HHS"],"pagination":["148-153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11225593"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["117(1)"],"pubmed_abstract":["Purpose
Lymphovascular space invasion (LVSI) predicts for higher rates of recurrence and increased mortality in endometrial cancer. Using 3-tier LVSI scoring, a PORTEC-1 and -2 trials analysis demonstrated that substantial LVSI was associated with worse locoregional (LR-DFS) and distant metastasis disease-free survival (DM-DFS), and these patients possibly benefited from external beam radiation therapy (EBRT). Furthermore, LVSI is a predictor for lymph node (LN) involvement, but the significance of substantial LVSI is unknown in patients with a pathologically negative LN assessment. We aimed to evaluate clinical outcomes of these patients in relation to the 3-tier LVSI scoring system.Methods and materials
We performed a single-institutional retrospective review of patients "],"journal":["International journal of radiation oncology, biology, physics"],"pubmed_title":["Is Substantial Lymphovascular Space Invasion Prognostic in Patients With Pathologically Lymph Node-Negative Endometrial Cancer?"],"pmcid":["PMC11225593"],"funding_grant_id":["P30 CA047904"],"pubmed_authors":["Vargo JA","Edwards R","Courtney-Brooks M","Cohen M","Jaishankar S","Taylor S","Bhargava R","Olawaiye A","Keller A","Beriwal S","Musunuru HB","Sukumvanich P","Berger JL","Lesnock J","Schad MD","Pifer PM","Boisen M"],"additional_accession":[]},"is_claimable":false,"name":"Is Substantial Lymphovascular Space Invasion Prognostic in Patients With Pathologically Lymph Node-Negative Endometrial Cancer?","description":"Purpose
Lymphovascular space invasion (LVSI) predicts for higher rates of recurrence and increased mortality in endometrial cancer. Using 3-tier LVSI scoring, a PORTEC-1 and -2 trials analysis demonstrated that substantial LVSI was associated with worse locoregional (LR-DFS) and distant metastasis disease-free survival (DM-DFS), and these patients possibly benefited from external beam radiation therapy (EBRT). Furthermore, LVSI is a predictor for lymph node (LN) involvement, but the significance of substantial LVSI is unknown in patients with a pathologically negative LN assessment. We aimed to evaluate clinical outcomes of these patients in relation to the 3-tier LVSI scoring system.Methods and materials
We performed a single-institutional retrospective review of patients ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-04-05T18:35:10.062Z","creation":"2025-04-05T18:35:10.062Z"},"accession":"S-EPMC11225593","cross_references":{"pubmed":["36893818"],"doi":["10.1016/j.ijrobp.2023.02.053"]}}