{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Laragione T"],"funding":["NIAMS","NIAMS NIH HHS","Icahn School of Medicine at Mount Sinai"],"pagination":["110158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11225809"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(6)"],"pubmed_abstract":["Receptor tyrosine kinases (RTKs) have an important role in arthritis severity and in models of rheumatoid arthritis (RA), but their regulation is not fully understood. The dual specificity phosphatase 6 (DUSP6) has been implicated in the regulation of RTK signaling, but never in the context of arthritis and autoimmunity. We used the KRN serum-induced arthritis (KSIA) model of RA and showed that DUSP6<sup>-/-</sup> mice were protected and had a 50% lower maximum arthritis score (<i>p</i> = 0.006) and reduced joint damage than C57BL/6 DUSP6+/+ controls. Serum levels of interleukin (IL) 10 were significantly increased (>2-fold), and IL6 decreased in DUSP6<sup>-/-</sup> mice. DUSP6<sup>-/-</sup> mice had increased numbers of IL10+ cells including Tr1 regulatory cells (<i>p</i> < 0.01). Introdu"],"journal":["iScience"],"pubmed_title":["DUSP6 deletion protects mice and reduces disease severity in autoimmune arthritis."],"pmcid":["PMC11225809"],"funding_grant_id":["R01 AR073165"],"pubmed_authors":["Rice N","Laragione T","Harris C","Gulko PS"],"additional_accession":[]},"is_claimable":false,"name":"DUSP6 deletion protects mice and reduces disease severity in autoimmune arthritis.","description":"Receptor tyrosine kinases (RTKs) have an important role in arthritis severity and in models of rheumatoid arthritis (RA), but their regulation is not fully understood. The dual specificity phosphatase 6 (DUSP6) has been implicated in the regulation of RTK signaling, but never in the context of arthritis and autoimmunity. We used the KRN serum-induced arthritis (KSIA) model of RA and showed that DUSP6<sup>-/-</sup> mice were protected and had a 50% lower maximum arthritis score (<i>p</i> = 0.006) and reduced joint damage than C57BL/6 DUSP6+/+ controls. Serum levels of interleukin (IL) 10 were significantly increased (>2-fold), and IL6 decreased in DUSP6<sup>-/-</sup> mice. DUSP6<sup>-/-</sup> mice had increased numbers of IL10+ cells including Tr1 regulatory cells (<i>p</i> < 0.01). Introdu","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-05-29T09:57:33.92Z","creation":"2025-04-04T12:22:12.491Z"},"accession":"S-EPMC11225809","cross_references":{"pubmed":["38974475"],"doi":["10.1016/j.isci.2024.110158"]}}