{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(7)"],"submitter":["Pisano ECL"],"funding":["Biotronik SE &amp; Co KG","Biotronik SE & Co KG"],"pubmed_abstract":["<h4>Aims</h4>Subclinical atrial fibrillation (AF) is associated with increased risk of progression to clinical AF, stroke, and cardiovascular death. We hypothesized that in pacemaker patients requiring dual-chamber rate-adaptive (DDDR) pacing, closed loop stimulation (CLS) integrated into the circulatory control system through intra-cardiac impedance monitoring would reduce the occurrence of atrial high-rate episodes (AHREs) compared with conventional DDDR pacing.<h4>Methods and results</h4>Patients with sinus node dysfunctions (SNDs) and an implanted pacemaker or defibrillator were randomly allocated to dual-chamber CLS (n = 612) or accelerometer-based DDDR pacing (n = 598) and followed for 3 years. The primary endpoint was time to the composite endpoint of the first AHRE lasting ≥6 min, "],"journal":["Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology"],"pagination":["euae175"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11226787"],"repository":["biostudies-literature"],"pubmed_title":["Closed loop stimulation reduces the incidence of atrial high-rate episodes compared with conventional rate-adaptive pacing in patients with sinus node dysfunctions."],"pmcid":["PMC11226787"],"pubmed_authors":["Coppolino A","Merkely B","Menichelli M","Ching CK","Botto GL","Carretta DM","Arena G","Pelargonio G","Gargaro A","Saporito D","Del Maestro M","Lazzari L","Su X","Rapacciuolo A","Del Castillo AM","Calvi V","Nicosia A","Bertaglia E","Viscusi M","Caccavo V","Lin LY","Giacopelli D","Wang CC","Bontempi L","Oh IY","Pisano ECL"],"additional_accession":[]},"is_claimable":false,"name":"Closed loop stimulation reduces the incidence of atrial high-rate episodes compared with conventional rate-adaptive pacing in patients with sinus node dysfunctions.","description":"<h4>Aims</h4>Subclinical atrial fibrillation (AF) is associated with increased risk of progression to clinical AF, stroke, and cardiovascular death. We hypothesized that in pacemaker patients requiring dual-chamber rate-adaptive (DDDR) pacing, closed loop stimulation (CLS) integrated into the circulatory control system through intra-cardiac impedance monitoring would reduce the occurrence of atrial high-rate episodes (AHREs) compared with conventional DDDR pacing.<h4>Methods and results</h4>Patients with sinus node dysfunctions (SNDs) and an implanted pacemaker or defibrillator were randomly allocated to dual-chamber CLS (n = 612) or accelerometer-based DDDR pacing (n = 598) and followed for 3 years. The primary endpoint was time to the composite endpoint of the first AHRE lasting ≥6 min, ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-02T22:49:20.611Z","creation":"2025-04-04T12:21:57.031Z"},"accession":"S-EPMC11226787","cross_references":{"pubmed":["38938169"],"doi":["10.1093/europace/euae175"]}}