{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(6)"],"submitter":["Ye G"],"funding":["National Natural Science Foundation of China","Zhejiang Province Natural Science Foundation"],"pubmed_abstract":["Lung cancer ranks the top of malignancies that cause cancer-related deaths worldwide. The leaves of <i>Morus alba</i> L are traditional Chinese medicine widely applied in respiratory diseases. Our previous work has demonstrated the anti-lung cancer effect of secondary metabolites of mulberry leaf, but their mechanism of action has still not fully elucidated. We synthesized Moracin N (MAN)-Probe conjugated with alkyne to label lung cancer cells and identified protein targets by chemical proteomic analysis. MAN and its probe exerted similar growth-inhibitory effect on human lung cancer cells. Chemical proteomic results showed that MAN targeted the programmed death ligand 1 (PD-L1) checkpoint pathway and T cell receptor (TCR) signaling pathway, indicating its immune-regulatory function. Cell-"],"journal":["Journal of pharmaceutical analysis"],"pagination":["100926"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11226898"],"repository":["biostudies-literature"],"pubmed_title":["Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway."],"pmcid":["PMC11226898"],"pubmed_authors":["Gao R","Li J","Mai Y","Zhang J","Ye G","Sun X"],"additional_accession":[]},"is_claimable":false,"name":"Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway.","description":"Lung cancer ranks the top of malignancies that cause cancer-related deaths worldwide. The leaves of <i>Morus alba</i> L are traditional Chinese medicine widely applied in respiratory diseases. Our previous work has demonstrated the anti-lung cancer effect of secondary metabolites of mulberry leaf, but their mechanism of action has still not fully elucidated. We synthesized Moracin N (MAN)-Probe conjugated with alkyne to label lung cancer cells and identified protein targets by chemical proteomic analysis. MAN and its probe exerted similar growth-inhibitory effect on human lung cancer cells. Chemical proteomic results showed that MAN targeted the programmed death ligand 1 (PD-L1) checkpoint pathway and T cell receptor (TCR) signaling pathway, indicating its immune-regulatory function. Cell-","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-05-23T03:13:08.823Z","creation":"2026-05-23T03:08:12.771Z"},"accession":"S-EPMC11226898","cross_references":{"pubmed":["38974523"],"doi":["10.1016/j.jpha.2023.12.016"]}}