{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin Y"],"funding":["NHLBI NIH HHS","NCI NIH HHS"],"pagination":["974-988.e5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11227404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(7)"],"pubmed_abstract":["Cellular therapies with cardiomyocytes produced from induced pluripotent stem cells (iPSC-CMs) offer a potential route to cardiac regeneration as a treatment for chronic ischemic heart disease. Here, we report successful long-term engraftment and in vivo maturation of autologous iPSC-CMs in two rhesus macaques with small, subclinical chronic myocardial infarctions, all without immunosuppression. Longitudinal positron emission tomography imaging using the sodium/iodide symporter (NIS) reporter gene revealed stable grafts for over 6 and 12 months, with no teratoma formation. Histological analyses suggested capability of the transplanted iPSC-CMs to mature and integrate with endogenous myocardium, with no sign of immune cell infiltration or rejection. By contrast, allogeneic iPSC-CMs were rej"],"journal":["Cell stem cell"],"pubmed_title":["Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques."],"pmcid":["PMC11227404"],"funding_grant_id":["R01 HL148081","75N91019D00024","R01 HL146868"],"pubmed_authors":["Zou J","Schwartzbeck R","Lin Y","Taylor JL","Murry CE","Jeffries KR","Boehm M","Kelly C","Ferrante EA","Yu SJ","Adler SS","Keeran KJ","Nakamura K","Chen MY","Clevenger RR","Dunbar CE","Hunt TJ","Yang X","Choyke PL","Neidig LE","Navarengom K","Mehta A","Sato N","Yu ZX","Takeda K","Hong S","Nakamura DS"],"additional_accession":[]},"is_claimable":false,"name":"Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques.","description":"Cellular therapies with cardiomyocytes produced from induced pluripotent stem cells (iPSC-CMs) offer a potential route to cardiac regeneration as a treatment for chronic ischemic heart disease. Here, we report successful long-term engraftment and in vivo maturation of autologous iPSC-CMs in two rhesus macaques with small, subclinical chronic myocardial infarctions, all without immunosuppression. Longitudinal positron emission tomography imaging using the sodium/iodide symporter (NIS) reporter gene revealed stable grafts for over 6 and 12 months, with no teratoma formation. Histological analyses suggested capability of the transplanted iPSC-CMs to mature and integrate with endogenous myocardium, with no sign of immune cell infiltration or rejection. By contrast, allogeneic iPSC-CMs were rej","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-07-28T03:03:45.009Z","creation":"2025-07-28T03:03:45.009Z"},"accession":"S-EPMC11227404","cross_references":{"pubmed":["38843830"],"doi":["10.1016/j.stem.2024.05.005"]}}