biostudies-literatureKnihtila HMThe Paulo FoundationNIEHS NIH HHSNIH Office of the DirectorNHLBI NIH HHSNational Heart Lung and Blood InstituteLastentautien TutkimussäätiöNIH HHSJane and Aatos Erkko Fundation94-100.e13https://www.ebi.ac.uk/biostudies/studies/S-EPMC11227409biostudies-literatureUnknown154(1)<h4>Background</h4>Asthmatic symptoms often start during early childhood. Impulse oscillometry (IOS) is feasible in preschool children who may be unable to reliably perform spirometry measurements.<h4>Objective</h4>We sought to evaluate the use of IOS in a multicenter, multiethnic high-risk asthma cohort titled the Vitamin D Antenatal Asthma Reduction Trial.<h4>Methods</h4>The trial recruited pregnant women whose children were followed from birth to age 8 years. Lung function was assessed with IOS at ages 4, 5, and 6 years and spirometry at ages 5, 6, 7, and 8 years. Asthma status, respiratory symptoms, and medication use were assessed with repeated questionnaires from birth to age 8 years.<h4>Results</h4>In total, 220 children were included in this secondary analysis. Recent respiratory sThe Journal of allergy and clinical immunologyPreschool impulse oscillometry predicts active asthma and impaired lung function at school age.PMC11227409R01 HL091528P30 ES001247UH3 OD023268Knihtila HMZeiger RSLaranjo NBacharier LBLitonjua AACarey VJO'Connor GTWeiss STStubbs BJfalsePreschool impulse oscillometry predicts active asthma and impaired lung function at school age.<h4>Background</h4>Asthmatic symptoms often start during early childhood. Impulse oscillometry (IOS) is feasible in preschool children who may be unable to reliably perform spirometry measurements.<h4>Objective</h4>We sought to evaluate the use of IOS in a multicenter, multiethnic high-risk asthma cohort titled the Vitamin D Antenatal Asthma Reduction Trial.<h4>Methods</h4>The trial recruited pregnant women whose children were followed from birth to age 8 years. Lung function was assessed with IOS at ages 4, 5, and 6 years and spirometry at ages 5, 6, 7, and 8 years. Asthma status, respiratory symptoms, and medication use were assessed with repeated questionnaires from birth to age 8 years.<h4>Results</h4>In total, 220 children were included in this secondary analysis. Recent respiratory s2024-01-01T00:00:00Z2024 Jul2026-06-02T20:29:04.827Z2026-04-20T03:10:05.884ZS-EPMC112274093824472410.1016/j.jaci.2023.12.025