{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou S"],"funding":["Sun Yat-Sen Memorial Hospital Clinical Research 5010 Program"],"pagination":["e079940"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11227769"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(7)"],"pubmed_abstract":["<h4>Introduction</h4>Laparoscopic proximal gastrectomy with double flap technique (LPG-DFT) reconstruction has been used for proximal early gastric cancer in recent years. However, its feasibility and safety remain uncertain, as only a few retrospective studies have contained postoperative complications and long-term survival data. LPG-DFT for proximal early gastric cancer is still in the early stages of research. Large-scale, prospective randomised controlled trials (RCTs) are necessary to assess the value of LPG-DFT for proximal early gastric cancer.<h4>Methods and analysis</h4>This study is a multicentre, prospective, open-label, RCT that investigates the antireflux effect of LPG-DFT compared with laparoscopic total gastrectomy with Roux-en-Y (LTG-RY) reconstruction for proximal early g"],"journal":["BMJ open"],"pubmed_title":["Comparing the antireflux effect of laparoscopic proximal gastrectomy with double-flap technique reconstruction versus laparoscopic total gastrectomy with Roux-en-Y reconstruction for proximal early gastric cancer: study protocol for a multicentre, prospective, open-label, randomised controlled trial."],"pmcid":["PMC11227769"],"funding_grant_id":["SYSKY-2022-276-02"],"pubmed_authors":["Xie Y","Zhu Y","Zhou S","Tan J","Zhong G","Yang B","Zhong L","Han F"],"additional_accession":[]},"is_claimable":false,"name":"Comparing the antireflux effect of laparoscopic proximal gastrectomy with double-flap technique reconstruction versus laparoscopic total gastrectomy with Roux-en-Y reconstruction for proximal early gastric cancer: study protocol for a multicentre, prospective, open-label, randomised controlled trial.","description":"<h4>Introduction</h4>Laparoscopic proximal gastrectomy with double flap technique (LPG-DFT) reconstruction has been used for proximal early gastric cancer in recent years. However, its feasibility and safety remain uncertain, as only a few retrospective studies have contained postoperative complications and long-term survival data. LPG-DFT for proximal early gastric cancer is still in the early stages of research. Large-scale, prospective randomised controlled trials (RCTs) are necessary to assess the value of LPG-DFT for proximal early gastric cancer.<h4>Methods and analysis</h4>This study is a multicentre, prospective, open-label, RCT that investigates the antireflux effect of LPG-DFT compared with laparoscopic total gastrectomy with Roux-en-Y (LTG-RY) reconstruction for proximal early g","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-01T20:32:40.19Z","creation":"2025-04-06T08:21:51.235Z"},"accession":"S-EPMC11227769","cross_references":{"pubmed":["38964794"],"doi":["10.1136/bmjopen-2023-079940"]}}