{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang A"],"funding":["CAMS Innovation Fund for Medical Sciences","National Natural Science Foundation of China"],"pagination":["154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11228008"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF) are Philadelphia chromosome-negative myeloproliferative neoplasms. These conditions share overlapping clinical presentations; however, their prognoses differ significantly. Current morphological diagnostic methods lack reliability in subtype differentiation, underlining the need for improved diagnostics. The aim of this study was to investigate the multi-omics alterations in bone marrow biopsies of patients with ET and pre-PMF to improve our understanding of the nuanced diagnostic characteristics of both diseases. We performed proteomic analysis with 4D direct data-independent acquisition and microbiome analysis with 2bRAD-M sequencing technology to identify differential protein and microbe levels between untrea"],"journal":["Clinical and experimental medicine"],"pubmed_title":["Multi-omics differences in the bone marrow between essential thrombocythemia and prefibrotic primary myelofibrosis."],"pmcid":["PMC11228008"],"funding_grant_id":["82000136","82270152","2023-I2M-QJ-015","82100151"],"pubmed_authors":["Fu R","Xue F","Li H","Chen J","Gu W","Sun T","Yu D","Zhang L","Liu W","Dai X","Liu X","Dong H","Wang W","Yang R","Chen Y","Ju M","Chi Y","Zhang A"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omics differences in the bone marrow between essential thrombocythemia and prefibrotic primary myelofibrosis.","description":"Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF) are Philadelphia chromosome-negative myeloproliferative neoplasms. These conditions share overlapping clinical presentations; however, their prognoses differ significantly. Current morphological diagnostic methods lack reliability in subtype differentiation, underlining the need for improved diagnostics. The aim of this study was to investigate the multi-omics alterations in bone marrow biopsies of patients with ET and pre-PMF to improve our understanding of the nuanced diagnostic characteristics of both diseases. We performed proteomic analysis with 4D direct data-independent acquisition and microbiome analysis with 2bRAD-M sequencing technology to identify differential protein and microbe levels between untrea","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-26T05:42:14.143Z","creation":"2025-04-06T11:35:24.609Z"},"accession":"S-EPMC11228008","cross_references":{"pubmed":["38972952"],"doi":["10.1007/s10238-024-01350-y"]}}