biostudies-literatureWang RFundamental Research Funds for Central Universities of the Central South UniversityThe 111 projectNational Natural Science Foundation of ChinaInstitutional Research Fund from Sichuan University0406https://www.ebi.ac.uk/biostudies/studies/S-EPMC11228074biostudies-literatureUnknown7Organic polymer materials, as the most abundantly produced materials, possess a flammable nature, making them potential hazards to human casualties and property losses. Target polymer design is still hindered due to the lack of a scientific foundation. Herein, we present a robust, generalizable, yet intelligent polymer discovery framework, which synergizes diverse capabilities, including the in situ burning analyzer, virtual reaction generator, and material genomic model, to achieve results that surpass the sum of individual parts. Notably, the high-throughput analyzer created for the first time, grounded in multiple spectroscopic principles, enables in situ capturing of massive combustion intermediates; then, the created realistic apparatus transforming to the virtual reaction generator aResearch (Washington, D.C.)Scientific Discovery Framework Accelerating Advanced Polymeric Materials Design.PMC1122807451827803B20001No.2021SCUNL201Wang XLFu TWang RSong XYang YJWang YZfalseScientific Discovery Framework Accelerating Advanced Polymeric Materials Design.Organic polymer materials, as the most abundantly produced materials, possess a flammable nature, making them potential hazards to human casualties and property losses. Target polymer design is still hindered due to the lack of a scientific foundation. Herein, we present a robust, generalizable, yet intelligent polymer discovery framework, which synergizes diverse capabilities, including the in situ burning analyzer, virtual reaction generator, and material genomic model, to achieve results that surpass the sum of individual parts. Notably, the high-throughput analyzer created for the first time, grounded in multiple spectroscopic principles, enables in situ capturing of massive combustion intermediates; then, the created realistic apparatus transforming to the virtual reaction generator a2024-01-01T00:00:00Z20242025-04-04T11:24:34.637Z2025-04-04T11:24:34.637ZS-EPMC112280743897951410.34133/research.0406