biostudies-literatureSchmolzer GMThrasher Research FundInstitute of Circulatory and Respiratory Health428-435https://www.ebi.ac.uk/biostudies/studies/S-EPMC11228189biostudies-literatureUnknown109(4)<h4>Objective</h4>In newborn infants requiring chest compression (CC) in the delivery room (DR) does continuous CC superimposed by a sustained inflation (CC+SI) compared with a 3:1 compression:ventilation (3:1 C:V) ratio decreases time to return of spontaneous circulation (ROSC).<h4>Design</h4>International, multicenter, prospective, cluster cross-over randomised trial.<h4>Setting</h4>DR in four hospitals in Canada and Austria, PARTICIPANTS: Newborn infants >28 weeks' gestation who required CC.<h4>Interventions</h4>Hospitals were randomised to CC+SI or 3:1 C:V then crossed over to the other intervention.<h4>Main outcome measure</h4>The primary outcome was time to ROSC, defined as the duration of CC until an increase in heart rate >60/min determined by auscultation of the heart, which was mArchives of disease in childhood. Fetal and neonatal edition<u>Su</u>stained inflation and chest comp<u>r</u>ession <u>v</u>ersus 3:<u>1</u> chest compression to <u>v</u>entilation ratio during cardiopulmonary resuscitation of asphyxiated n<u>e</u>wborns (SURV1VE): A cluster randomised controlled trial.PMC11228189ECIACRR 155222Pfurtscheller DPichler GYaskina MSolevag ALCheung PYSchmolzer GMWagner MLaw BHYSURV1VE- Trial InvestigatorsMitra Sfalse<u>Su</u>stained inflation and chest comp<u>r</u>ession <u>v</u>ersus 3:<u>1</u> chest compression to <u>v</u>entilation ratio during cardiopulmonary resuscitation of asphyxiated n<u>e</u>wborns (SURV1VE): A cluster randomised controlled trial.<h4>Objective</h4>In newborn infants requiring chest compression (CC) in the delivery room (DR) does continuous CC superimposed by a sustained inflation (CC+SI) compared with a 3:1 compression:ventilation (3:1 C:V) ratio decreases time to return of spontaneous circulation (ROSC).<h4>Design</h4>International, multicenter, prospective, cluster cross-over randomised trial.<h4>Setting</h4>DR in four hospitals in Canada and Austria, PARTICIPANTS: Newborn infants >28 weeks' gestation who required CC.<h4>Interventions</h4>Hospitals were randomised to CC+SI or 3:1 C:V then crossed over to the other intervention.<h4>Main outcome measure</h4>The primary outcome was time to ROSC, defined as the duration of CC until an increase in heart rate >60/min determined by auscultation of the heart, which was m2024-01-01T00:00:00Z2024 Jun2026-06-07T07:48:21.641Z2026-06-07T03:11:52.91ZS-EPMC112281893821210410.1136/archdischild-2023-326383