{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zeng S"],"funding":["NIAID NIH HHS","NIAID"],"pagination":["1511-1525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11228286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(10)"],"pubmed_abstract":["Human leukocyte antigen antibodies are important immunologic mediators of renal allograft loss and are difficult to control. The inability to permanently eliminate donor-specific antibodies (DSA) is partly due to an incomplete understanding of the cellular mechanisms driving alloantibody formation, recurrence, and maintenance. Memory T follicular helper (mTfh) cells rapidly interact with memory B cells upon antigen re-exposure for anamnestic humoral responses, but little is known about Tfh memory in transplantation. We hypothesized that alloreactive mTfh cells form after transplantation and play a critical role in DSA formation following alloantigen re-encounter. To test this hypothesis, we utilized murine skin allograft models to identify and characterize Tfh memory and interrogate its ab"],"journal":["American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"],"pubmed_title":["Memory T follicular helper cells drive donor-specific antibodies independent of memory B cells and primary germinal center and alloantibody formation."],"pmcid":["PMC11228286"],"funding_grant_id":["R01 AI164716","T32 AI070081","K08 AI132747"],"pubmed_authors":["Zeng S","Ford ML","Crichton ES","Badell IR"],"additional_accession":[]},"is_claimable":false,"name":"Memory T follicular helper cells drive donor-specific antibodies independent of memory B cells and primary germinal center and alloantibody formation.","description":"Human leukocyte antigen antibodies are important immunologic mediators of renal allograft loss and are difficult to control. The inability to permanently eliminate donor-specific antibodies (DSA) is partly due to an incomplete understanding of the cellular mechanisms driving alloantibody formation, recurrence, and maintenance. Memory T follicular helper (mTfh) cells rapidly interact with memory B cells upon antigen re-exposure for anamnestic humoral responses, but little is known about Tfh memory in transplantation. We hypothesized that alloreactive mTfh cells form after transplantation and play a critical role in DSA formation following alloantigen re-encounter. To test this hypothesis, we utilized murine skin allograft models to identify and characterize Tfh memory and interrogate its ab","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2025-04-18T12:58:15.372Z","creation":"2025-04-06T22:24:34.945Z"},"accession":"S-EPMC11228286","cross_references":{"pubmed":["37302575"],"doi":["10.1016/j.ajt.2023.06.006"]}}