{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lehmann J"],"funding":["Deutsche Forschungsgemeinschaft","Martin-Luther-Universität Halle-Wittenberg"],"pagination":["150"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11229289"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>Accurate detection of pheromones is crucial for chemical communication and reproduction in insects. In holometabolous flies and moths, the sensory neuron membrane protein 1 (SNMP1) is essential for detecting long-chain aliphatic pheromones by olfactory neurons. However, its function in hemimetabolous insects and its role for detecting pheromones of a different chemical nature remain elusive. Therefore, we investigated the relevance of SNMP1 for pheromone detection in a hemimetabolous insect pest of considerable economic importance, the desert locust Schistocerca gregaria, which moreover employs the aromatic pheromone phenylacetonitrile (PAN) to govern reproductive behaviors.<h4>Results</h4>Employing CRISPR/Cas-mediated gene editing, a mutant locust line lacking functiona"],"journal":["BMC biology"],"pubmed_title":["SNMP1 is critical for sensitive detection of the desert locust aromatic courtship inhibition pheromone phenylacetonitrile."],"pmcid":["PMC11229289"],"funding_grant_id":["EXC 2117 - 422037984","KR1786/5-1"],"pubmed_authors":["Khosravian M","Fleischer J","Gunzel Y","Kraus S","Hansson BS","Lehmann J","Breer H","Couzin-Fuchs E","Libnow JS","Chang H","Krieger J","Cassau S"],"additional_accession":[]},"is_claimable":false,"name":"SNMP1 is critical for sensitive detection of the desert locust aromatic courtship inhibition pheromone phenylacetonitrile.","description":"<h4>Background</h4>Accurate detection of pheromones is crucial for chemical communication and reproduction in insects. In holometabolous flies and moths, the sensory neuron membrane protein 1 (SNMP1) is essential for detecting long-chain aliphatic pheromones by olfactory neurons. However, its function in hemimetabolous insects and its role for detecting pheromones of a different chemical nature remain elusive. Therefore, we investigated the relevance of SNMP1 for pheromone detection in a hemimetabolous insect pest of considerable economic importance, the desert locust Schistocerca gregaria, which moreover employs the aromatic pheromone phenylacetonitrile (PAN) to govern reproductive behaviors.<h4>Results</h4>Employing CRISPR/Cas-mediated gene editing, a mutant locust line lacking functiona","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-07-15T05:14:43.99Z","creation":"2025-04-04T11:25:29.448Z"},"accession":"S-EPMC11229289","cross_references":{"pubmed":["38973001"],"doi":["10.1186/s12915-024-01941-x"]}}