{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["Natural Science Foundation of Zhejiang Province","State Key Laboratory Foundation for Diagnosis and Treatment of Infectious Diseases","National Natural Science Foundation of China","Hangzhou Youth Innovation Team Project","Scientific Research Foundation for Scholars of HZNU"],"pagination":["7142-7157"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11229311"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(12)"],"pubmed_abstract":["DHH/DHHA1 family proteins have been proposed to play critical roles in bacterial resistance to environmental stresses. Members of the most radioresistant bacteria genus, Deinococcus, possess two DHH/DHHA1 family proteins, RecJ and RecJ-like. While the functions of Deinococcus radiodurans RecJ (DrRecJ) in DNA damage resistance have been well characterized, the role and biochemical activities of D. radiodurans RecJ-like (DrRecJ-like) remain unclear. Phenotypic and transcriptomic analyses suggest that, beyond DNA repair, DrRecJ is implicated in cell growth and division. Additionally, DrRecJ-like not only affects stress response, cell growth, and division but also correlates with the folding/stability of intracellular proteins, as well as the formation and stability of cell membranes/walls. Dr"],"journal":["Nucleic acids research"],"pubmed_title":["Structural and functional investigation of the DHH/DHHA1 family proteins in Deinococcus radiodurans."],"pmcid":["PMC11229311"],"funding_grant_id":["LQ22C050002","32200146","32270043","TD2023020","4255C50222204016","zz202309","4125C50221204040","32100017"],"pubmed_authors":["Yang J","Guo Z","Cheng K","Hao W","Luo Y","Wang Y","Sun Y","Wu Y","Gao T","Jin L"],"additional_accession":[]},"is_claimable":false,"name":"Structural and functional investigation of the DHH/DHHA1 family proteins in Deinococcus radiodurans.","description":"DHH/DHHA1 family proteins have been proposed to play critical roles in bacterial resistance to environmental stresses. Members of the most radioresistant bacteria genus, Deinococcus, possess two DHH/DHHA1 family proteins, RecJ and RecJ-like. While the functions of Deinococcus radiodurans RecJ (DrRecJ) in DNA damage resistance have been well characterized, the role and biochemical activities of D. radiodurans RecJ-like (DrRecJ-like) remain unclear. Phenotypic and transcriptomic analyses suggest that, beyond DNA repair, DrRecJ is implicated in cell growth and division. Additionally, DrRecJ-like not only affects stress response, cell growth, and division but also correlates with the folding/stability of intracellular proteins, as well as the formation and stability of cell membranes/walls. Dr","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-04-08T19:22:12.242Z","creation":"2025-04-04T11:25:34.227Z"},"accession":"S-EPMC11229311","cross_references":{"pubmed":["38804263"],"doi":["10.1093/nar/gkae451"]}}