{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sugiaman VK"],"funding":["The Maranatha Christian University which provided fund for this research"],"pagination":["e17642"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11229682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["<h4>Background</h4>Gingivitis is an inflammation of the gums that is the initial cause of the development of periodontal disease by the activity of Nuclear Factor-kappa B (NF-κB), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), p38, and Tumor Necrosis Factor-α (TNF-α). Unaddressed chronic inflammation can lead to persistent disturbances in other parts of the body. Brazilin is a naturally occurring plant chemical that may have antibacterial and anti-inflammatory effects. Treatment based on the natural plant compound, brazilin, is developed in the form of a topical cream for easy application.<h4>Objective</h4>The aim is to develop the natural compound brazilin in the form of a topical cream as an anti-inflammatory agent to reduce NF-κB expression through Imunohistochemistry (IHC) methods, and "],"journal":["PeerJ"],"pubmed_title":["Brazilin cream from <i>Caesalpinia sappan</i> inhibit periodontal disease: <i>in vivo</i> study."],"pmcid":["PMC11229682"],"funding_grant_id":["007/PRJ-GB/UKM/I/2023"],"pubmed_authors":["Ferdiansyah R","Sugiaman VK","Pranata N","Jeffrey J","Naliani S","Lelyana S","Widowati W","Ayuni V","Hadiprasetyo DS"],"additional_accession":[]},"is_claimable":false,"name":"Brazilin cream from <i>Caesalpinia sappan</i> inhibit periodontal disease: <i>in vivo</i> study.","description":"<h4>Background</h4>Gingivitis is an inflammation of the gums that is the initial cause of the development of periodontal disease by the activity of Nuclear Factor-kappa B (NF-κB), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), p38, and Tumor Necrosis Factor-α (TNF-α). Unaddressed chronic inflammation can lead to persistent disturbances in other parts of the body. Brazilin is a naturally occurring plant chemical that may have antibacterial and anti-inflammatory effects. Treatment based on the natural plant compound, brazilin, is developed in the form of a topical cream for easy application.<h4>Objective</h4>The aim is to develop the natural compound brazilin in the form of a topical cream as an anti-inflammatory agent to reduce NF-κB expression through Imunohistochemistry (IHC) methods, and ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T13:37:10.489Z","creation":"2025-04-04T11:26:26.984Z"},"accession":"S-EPMC11229682","cross_references":{"pubmed":["38978754"],"doi":["10.7717/peerj.17642"]}}