biostudies-literatureSugiaman VKThe Maranatha Christian University which provided fund for this researche17642https://www.ebi.ac.uk/biostudies/studies/S-EPMC11229682biostudies-literatureUnknown12<h4>Background</h4>Gingivitis is an inflammation of the gums that is the initial cause of the development of periodontal disease by the activity of Nuclear Factor-kappa B (NF-κB), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), p38, and Tumor Necrosis Factor-α (TNF-α). Unaddressed chronic inflammation can lead to persistent disturbances in other parts of the body. Brazilin is a naturally occurring plant chemical that may have antibacterial and anti-inflammatory effects. Treatment based on the natural plant compound, brazilin, is developed in the form of a topical cream for easy application.<h4>Objective</h4>The aim is to develop the natural compound brazilin in the form of a topical cream as an anti-inflammatory agent to reduce NF-κB expression through Imunohistochemistry (IHC) methods, and PeerJBrazilin cream from <i>Caesalpinia sappan</i> inhibit periodontal disease: <i>in vivo</i> study.PMC11229682007/PRJ-GB/UKM/I/2023Ferdiansyah RSugiaman VKPranata NJeffrey JNaliani SLelyana SWidowati WAyuni VHadiprasetyo DSfalseBrazilin cream from <i>Caesalpinia sappan</i> inhibit periodontal disease: <i>in vivo</i> study.<h4>Background</h4>Gingivitis is an inflammation of the gums that is the initial cause of the development of periodontal disease by the activity of Nuclear Factor-kappa B (NF-κB), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), p38, and Tumor Necrosis Factor-α (TNF-α). Unaddressed chronic inflammation can lead to persistent disturbances in other parts of the body. Brazilin is a naturally occurring plant chemical that may have antibacterial and anti-inflammatory effects. Treatment based on the natural plant compound, brazilin, is developed in the form of a topical cream for easy application.<h4>Objective</h4>The aim is to develop the natural compound brazilin in the form of a topical cream as an anti-inflammatory agent to reduce NF-κB expression through Imunohistochemistry (IHC) methods, and 2024-01-01T00:00:00Z20242026-06-01T13:37:10.489Z2025-04-04T11:26:26.984ZS-EPMC112296823897875410.7717/peerj.17642