{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Dong J"],"pubmed_abstract":["<h4>Background</h4>Oligospermia is one of the most common reasons for male infertility which is troubling numerous couples of child-bearing age. This investigation scrutinizes the implications and mechanistic underpinnings of ursolic acid's effect on busulfan-induced oligospermia in mouse models.<h4>Methods</h4>A singular intraperitoneal injection of busulfan at a dosage of 30 mg/kg induced oligospermia. Two weeks subsequent to this induction, mice were subjected to various dosages of ursolic acid (10, 30, and 50 mg/kg body weight, respectively) on a daily basis for four consecutive weeks. Following this treatment period, a meticulous analysis of epididymal sperm parameters, encompassing concentration and motility, was conducted using a computer-assisted sperm analysis system. The histopat"],"journal":["PeerJ"],"pagination":["e17691"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11229684"],"repository":["biostudies-literature"],"pubmed_title":["Ursolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins."],"pmcid":["PMC11229684"],"pubmed_authors":["Dong Y","Dong J","Ye T","Hui J","Wang X"],"additional_accession":[]},"is_claimable":false,"name":"Ursolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins.","description":"<h4>Background</h4>Oligospermia is one of the most common reasons for male infertility which is troubling numerous couples of child-bearing age. This investigation scrutinizes the implications and mechanistic underpinnings of ursolic acid's effect on busulfan-induced oligospermia in mouse models.<h4>Methods</h4>A singular intraperitoneal injection of busulfan at a dosage of 30 mg/kg induced oligospermia. Two weeks subsequent to this induction, mice were subjected to various dosages of ursolic acid (10, 30, and 50 mg/kg body weight, respectively) on a daily basis for four consecutive weeks. Following this treatment period, a meticulous analysis of epididymal sperm parameters, encompassing concentration and motility, was conducted using a computer-assisted sperm analysis system. The histopat","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T07:37:46.152Z","creation":"2025-04-04T11:24:40.537Z"},"accession":"S-EPMC11229684","cross_references":{"pubmed":["38978752"],"doi":["10.7717/peerj.17691"]}}