{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(4)"],"submitter":["Miller K"],"funding":["National Audit of Breast Cancer in Older Patients","National Clinical Audit and Patient Outcomes","Welsh Government","Healthcare Quality Improvement Partnership","NHS England"],"pubmed_abstract":["<h4>Background</h4>This study assessed the influence of age, co-morbidity and frailty on 5-year survival outcomes after breast conservation surgery (BCS) with radiotherapy (RT) versus mastectomy (with or without RT) in women with early invasive breast cancer.<h4>Methods</h4>Women aged over 50 years with early invasive breast cancer diagnosed in England (2014-2019) who had breast surgery were identified from Cancer Registry data. Survival estimates were calculated from a flexible parametric survival model. A competing risk approach was used for breast cancer-specific survival (BCSS). Standardized survival probabilities and cumulative incidence functions for breast cancer death were calculated for each treatment by age.<h4>Results</h4>Among 101 654 women, 72.2% received BCS + RT and 27.8% re"],"journal":["BJS open"],"pagination":["zrae062"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11229699"],"repository":["biostudies-literature"],"pubmed_title":["Survival outcomes after breast cancer surgery among older women with early invasive breast cancer in England: population-based cohort study."],"pmcid":["PMC11229699"],"pubmed_authors":["Miller K","Park MH","Gannon MR","Medina J","Clements K","Dodwell D","Horgan K","Cromwell DA"],"additional_accession":[]},"is_claimable":false,"name":"Survival outcomes after breast cancer surgery among older women with early invasive breast cancer in England: population-based cohort study.","description":"<h4>Background</h4>This study assessed the influence of age, co-morbidity and frailty on 5-year survival outcomes after breast conservation surgery (BCS) with radiotherapy (RT) versus mastectomy (with or without RT) in women with early invasive breast cancer.<h4>Methods</h4>Women aged over 50 years with early invasive breast cancer diagnosed in England (2014-2019) who had breast surgery were identified from Cancer Registry data. Survival estimates were calculated from a flexible parametric survival model. A competing risk approach was used for breast cancer-specific survival (BCSS). Standardized survival probabilities and cumulative incidence functions for breast cancer death were calculated for each treatment by age.<h4>Results</h4>Among 101 654 women, 72.2% received BCS + RT and 27.8% re","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-04T11:25:30.609Z","creation":"2025-04-04T11:25:30.609Z"},"accession":"S-EPMC11229699","cross_references":{"pubmed":["38976577"],"doi":["10.1093/bjsopen/zrae062"]}}