biostudies-literatureUnknown8(4)Miller KNational Audit of Breast Cancer in Older PatientsNational Clinical Audit and Patient OutcomesWelsh GovernmentHealthcare Quality Improvement PartnershipNHS England<h4>Background</h4>This study assessed the influence of age, co-morbidity and frailty on 5-year survival outcomes after breast conservation surgery (BCS) with radiotherapy (RT) versus mastectomy (with or without RT) in women with early invasive breast cancer.<h4>Methods</h4>Women aged over 50 years with early invasive breast cancer diagnosed in England (2014-2019) who had breast surgery were identified from Cancer Registry data. Survival estimates were calculated from a flexible parametric survival model. A competing risk approach was used for breast cancer-specific survival (BCSS). Standardized survival probabilities and cumulative incidence functions for breast cancer death were calculated for each treatment by age.<h4>Results</h4>Among 101 654 women, 72.2% received BCS + RT and 27.8% reBJS openzrae062https://www.ebi.ac.uk/biostudies/studies/S-EPMC11229699biostudies-literatureSurvival outcomes after breast cancer surgery among older women with early invasive breast cancer in England: population-based cohort study.PMC11229699Miller KPark MHGannon MRMedina JClements KDodwell DHorgan KCromwell DAfalseSurvival outcomes after breast cancer surgery among older women with early invasive breast cancer in England: population-based cohort study.<h4>Background</h4>This study assessed the influence of age, co-morbidity and frailty on 5-year survival outcomes after breast conservation surgery (BCS) with radiotherapy (RT) versus mastectomy (with or without RT) in women with early invasive breast cancer.<h4>Methods</h4>Women aged over 50 years with early invasive breast cancer diagnosed in England (2014-2019) who had breast surgery were identified from Cancer Registry data. Survival estimates were calculated from a flexible parametric survival model. A competing risk approach was used for breast cancer-specific survival (BCSS). Standardized survival probabilities and cumulative incidence functions for breast cancer death were calculated for each treatment by age.<h4>Results</h4>Among 101 654 women, 72.2% received BCS + RT and 27.8% re2024-01-01T00:00:00Z2024 Jul2025-04-04T11:25:30.609Z2025-04-04T11:25:30.609ZS-EPMC112296993897657710.1093/bjsopen/zrae062