biostudies-literatureWu-Chung ELNIA NIH HHS512-522https://www.ebi.ac.uk/biostudies/studies/S-EPMC11230842biostudies-literatureUnknown86(6)<h4>Objective</h4>Chronic stress adversely affects mental and physical well-being. However, health outcomes vary among people experiencing the same stressor. Individual differences in physical and emotional well-being may depend on mitochondrial biology, as energy production is crucial for stress regulation. This study investigated whether mitochondrial respiratory capacity corresponds to individual differences in dementia spousal caregivers' mental and physical health.<h4>Methods</h4>Spousal caregivers of individuals with Alzheimer's disease and related dementias ( N = 102, mean age = 71, 78% female, 83% White) provided peripheral blood samples and completed self-report questionnaires on quality of life, caregiver burden, and a 7-day affect scale. Multiple and mixed linear regressions werPsychosomatic medicineMitochondrial Health, Physical Functioning, and Daily Affect: Bioenergetic Mechanisms of Dementia Caregiver Well-Being.PMC11230842F31 AG074648F32 AG079624Heijnen CJWu-Chung ELStinson JMMahant IFagundes CPLai VSchulz PEPaoletti-Hatcher JMedina LDfalseMitochondrial Health, Physical Functioning, and Daily Affect: Bioenergetic Mechanisms of Dementia Caregiver Well-Being.<h4>Objective</h4>Chronic stress adversely affects mental and physical well-being. However, health outcomes vary among people experiencing the same stressor. Individual differences in physical and emotional well-being may depend on mitochondrial biology, as energy production is crucial for stress regulation. This study investigated whether mitochondrial respiratory capacity corresponds to individual differences in dementia spousal caregivers' mental and physical health.<h4>Methods</h4>Spousal caregivers of individuals with Alzheimer's disease and related dementias ( N = 102, mean age = 71, 78% female, 83% White) provided peripheral blood samples and completed self-report questionnaires on quality of life, caregiver burden, and a 7-day affect scale. Multiple and mixed linear regressions wer2024-01-01T00:00:00Z2024 Jul-Aug 012025-06-26T03:05:34.726Z2025-06-26T03:05:34.726ZS-EPMC112308423866665410.1097/psy.000000000000131210.1097/PSY.0000000000001312