{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang T"],"funding":["Kungliga Tekniska Högskolan","Vetenskapsrådet","Svenska Forskningsrådet Formas","Government of Jiangsu Province","Priority Academic Program Development of Jiangsu Higher Education Institutions","Magnus Bergvalls Stiftelse","Olle Engkvists Stiftelse"],"pagination":["9298-9302"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11232002"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["89(13)"],"pubmed_abstract":["A silver-catalyzed protocol for the intermolecular radical umpolung cross-coupling protocol of silyl enol ethers with activated methylene compounds is disclosed. The protocol exhibits excellent functional group tolerance, enabling the expedient preparation of a variety of tricarbonyl compounds. Preliminary mechanistic investigations suggest that the reaction proceeds through a process involving free radicals in which silver oxide has a dual role, acting as both a catalyst and a base."],"journal":["The Journal of organic chemistry"],"pubmed_title":["Silver-Catalyzed Radical Umpolung Cross-Coupling of Silyl Enol Ethers with Activated Methylene Compounds: Access to Diverse Tricarbonyl Derivatives."],"pmcid":["PMC11232002"],"funding_grant_id":["2019-01269","2020-04764","BK20211607"],"pubmed_authors":["Xu L","Liang T","Karkas MD","Liu JQ","Yuan Q","Wang XS"],"additional_accession":[]},"is_claimable":false,"name":"Silver-Catalyzed Radical Umpolung Cross-Coupling of Silyl Enol Ethers with Activated Methylene Compounds: Access to Diverse Tricarbonyl Derivatives.","description":"A silver-catalyzed protocol for the intermolecular radical umpolung cross-coupling protocol of silyl enol ethers with activated methylene compounds is disclosed. The protocol exhibits excellent functional group tolerance, enabling the expedient preparation of a variety of tricarbonyl compounds. Preliminary mechanistic investigations suggest that the reaction proceeds through a process involving free radicals in which silver oxide has a dual role, acting as both a catalyst and a base.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-25T20:23:50.322Z","creation":"2025-04-06T08:19:56.162Z"},"accession":"S-EPMC11232002","cross_references":{"pubmed":["38877984"],"doi":["10.1021/acs.joc.4c00310"]}}