biostudies-literatureLiang TKungliga Tekniska HögskolanVetenskapsrådetSvenska Forskningsrådet FormasGovernment of Jiangsu ProvincePriority Academic Program Development of Jiangsu Higher Education InstitutionsMagnus Bergvalls StiftelseOlle Engkvists Stiftelse9298-9302https://www.ebi.ac.uk/biostudies/studies/S-EPMC11232002biostudies-literatureUnknown89(13)A silver-catalyzed protocol for the intermolecular radical umpolung cross-coupling protocol of silyl enol ethers with activated methylene compounds is disclosed. The protocol exhibits excellent functional group tolerance, enabling the expedient preparation of a variety of tricarbonyl compounds. Preliminary mechanistic investigations suggest that the reaction proceeds through a process involving free radicals in which silver oxide has a dual role, acting as both a catalyst and a base.The Journal of organic chemistrySilver-Catalyzed Radical Umpolung Cross-Coupling of Silyl Enol Ethers with Activated Methylene Compounds: Access to Diverse Tricarbonyl Derivatives.PMC112320022019-012692020-04764BK20211607Xu LLiang TKarkas MDLiu JQYuan QWang XSfalseSilver-Catalyzed Radical Umpolung Cross-Coupling of Silyl Enol Ethers with Activated Methylene Compounds: Access to Diverse Tricarbonyl Derivatives.A silver-catalyzed protocol for the intermolecular radical umpolung cross-coupling protocol of silyl enol ethers with activated methylene compounds is disclosed. The protocol exhibits excellent functional group tolerance, enabling the expedient preparation of a variety of tricarbonyl compounds. Preliminary mechanistic investigations suggest that the reaction proceeds through a process involving free radicals in which silver oxide has a dual role, acting as both a catalyst and a base.2024-01-01T00:00:00Z2024 Jul2025-04-25T20:23:50.322Z2025-04-06T08:19:56.162ZS-EPMC112320023887798410.1021/acs.joc.4c00310