biostudies-literatureQian XChina–Japan Friendship HospitalUS Centers for Disease Control and Prevention (CDC)–WHO Cooperative AgreementMinistry of Public Health of the People’s Republic of ChinaNational Center for Cardiovascular Diseases &amp; Fuwai HospitalWorld BankDa Qing First HospitalUS CDC–Chinese Center for Disease Control and Prevention Cooperative AgreementChinese Academy of Medical Sciences, Innovation Fund for Medical Sciencese1004419https://www.ebi.ac.uk/biostudies/studies/S-EPMC11233008biostudies-literatureUnknown21(7)<h4>Background</h4>The association between years of non-diabetes status after diagnosis of impaired glucose tolerance (IGT) and the risk of long-term death and cardiovascular outcomes needed to be clarified.<h4>Methods and findings</h4>In this post hoc analysis, we included 540 individuals with IGT who participated in the original Da Qing Diabetes Prevention Study (DQDPS). In the DQDPS, all participants were diagnosed with IGT by a 75 g oral glucose tolerance test and randomized to intervention or control groups with a 6-year lifestyle intervention trial. After the completion of the trial, death, cardiovascular events, and microvascular complications were monitored over a 30-year follow-up. In this post hoc analysis, the Cox analysis assessed the extended risk of these outcomes in individuPLoS medicineNon-diabetes status after diagnosis of impaired glucose tolerance and risk of long-term death and vascular complications: A post hoc analysis of the Da Qing Diabetes Prevention Outcome Study.PMC112330085U19GH000636–05U58/CCU424123–01–022020-I2M-2-006Li GGong QFeng XZhang LWang JQian XHe SZhai XHui YAn YWang WChen YChen XZhang BfalseNon-diabetes status after diagnosis of impaired glucose tolerance and risk of long-term death and vascular complications: A post hoc analysis of the Da Qing Diabetes Prevention Outcome Study.<h4>Background</h4>The association between years of non-diabetes status after diagnosis of impaired glucose tolerance (IGT) and the risk of long-term death and cardiovascular outcomes needed to be clarified.<h4>Methods and findings</h4>In this post hoc analysis, we included 540 individuals with IGT who participated in the original Da Qing Diabetes Prevention Study (DQDPS). In the DQDPS, all participants were diagnosed with IGT by a 75 g oral glucose tolerance test and randomized to intervention or control groups with a 6-year lifestyle intervention trial. After the completion of the trial, death, cardiovascular events, and microvascular complications were monitored over a 30-year follow-up. In this post hoc analysis, the Cox analysis assessed the extended risk of these outcomes in individu2024-01-01T00:00:00Z2024 Jul2025-04-25T20:23:08.512Z2025-04-06T08:19:52.323ZS-EPMC112330083898083710.1371/journal.pmed.1004419