{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(4)"],"submitter":["Merali S"],"funding":["Bristol-Myers Squibb"],"pubmed_abstract":["Objective
To assess the effect of activated charcoal on the single-dose pharmacokinetics of mavacamten when administered 2 h or 6 h after mavacamten dosing.Methods
In this open-label, randomized, parallel-group study, healthy adults were randomized into three groups to receive mavacamten 15 mg alone or mavacamten 15 mg plus activated charcoal 50 g administered either 2 h or 6 h after mavacamten dosing. Pharmacokinetic parameters were derived from plasma concentration-time data using noncompartmental methods.Results
Of the 45 participants randomized, 37 completed the study. When activated charcoal was administered 2 h after mavacamten dosing, mavacamten absorption and exposure were reduced compared with when mavacamten was administered alone: the area under the conce"],"journal":["American journal of cardiovascular drugs : drugs, devices, and other interventions"],"pagination":["569-575"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11233281"],"repository":["biostudies-literature"],"pubmed_title":["Effect of Activated Charcoal on Mavacamten Pharmacokinetics in Healthy Participants."],"pmcid":["PMC11233281"],"pubmed_authors":["Simmons T","Murthy B","Chao L","Attanasio M","Merali S","Zhao A","Sychterz C","Chiang M","Perera V","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Activated Charcoal on Mavacamten Pharmacokinetics in Healthy Participants.","description":"Objective
To assess the effect of activated charcoal on the single-dose pharmacokinetics of mavacamten when administered 2 h or 6 h after mavacamten dosing.Methods
In this open-label, randomized, parallel-group study, healthy adults were randomized into three groups to receive mavacamten 15 mg alone or mavacamten 15 mg plus activated charcoal 50 g administered either 2 h or 6 h after mavacamten dosing. Pharmacokinetic parameters were derived from plasma concentration-time data using noncompartmental methods.Results
Of the 45 participants randomized, 37 completed the study. When activated charcoal was administered 2 h after mavacamten dosing, mavacamten absorption and exposure were reduced compared with when mavacamten was administered alone: the area under the conce","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-05-29T11:59:13.377Z","creation":"2025-04-04T11:25:04.404Z"},"accession":"S-EPMC11233281","cross_references":{"pubmed":["38926266"],"doi":["10.1007/s40256-024-00659-z"]}}