biostudies-literatureUnknown24(4)Merali SBristol-Myers Squibb<h4>Objective</h4>To assess the effect of activated charcoal on the single-dose pharmacokinetics of mavacamten when administered 2 h or 6 h after mavacamten dosing.<h4>Methods</h4>In this open-label, randomized, parallel-group study, healthy adults were randomized into three groups to receive mavacamten 15 mg alone or mavacamten 15 mg plus activated charcoal 50 g administered either 2 h or 6 h after mavacamten dosing. Pharmacokinetic parameters were derived from plasma concentration-time data using noncompartmental methods.<h4>Results</h4>Of the 45 participants randomized, 37 completed the study. When activated charcoal was administered 2 h after mavacamten dosing, mavacamten absorption and exposure were reduced compared with when mavacamten was administered alone: the area under the conceAmerican journal of cardiovascular drugs : drugs, devices, and other interventions569-575https://www.ebi.ac.uk/biostudies/studies/S-EPMC11233281biostudies-literatureEffect of Activated Charcoal on Mavacamten Pharmacokinetics in Healthy Participants.PMC11233281Simmons TMurthy BChao LAttanasio MMerali SZhao ASychterz CChiang MPerera VXu YfalseEffect of Activated Charcoal on Mavacamten Pharmacokinetics in Healthy Participants.<h4>Objective</h4>To assess the effect of activated charcoal on the single-dose pharmacokinetics of mavacamten when administered 2 h or 6 h after mavacamten dosing.<h4>Methods</h4>In this open-label, randomized, parallel-group study, healthy adults were randomized into three groups to receive mavacamten 15 mg alone or mavacamten 15 mg plus activated charcoal 50 g administered either 2 h or 6 h after mavacamten dosing. Pharmacokinetic parameters were derived from plasma concentration-time data using noncompartmental methods.<h4>Results</h4>Of the 45 participants randomized, 37 completed the study. When activated charcoal was administered 2 h after mavacamten dosing, mavacamten absorption and exposure were reduced compared with when mavacamten was administered alone: the area under the conce2024-01-01T00:00:00Z2024 Jul2026-05-29T11:59:13.377Z2025-04-04T11:25:04.404ZS-EPMC112332813892626610.1007/s40256-024-00659-z