{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bartho LA"],"funding":["Department of Health | National Health and Medical Research Council (NHMRC)","Department of Health | National Health and Medical Research Council","Australian Research Council"],"pagination":["15829"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11233654"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Metabolomics is the study of small molecules (metabolites), within cells, tissues and biofluids. Maternal metabolites can provide important insight into the health and development of both mother and fetus throughout pregnancy. This study assessed metabolic profiles in the maternal circulation prior to and at the time of diagnosis of preeclampsia and fetal growth restriction. Maternal plasma samples were collected from two independent cohorts: (1) Established disease cohort: 50 participants diagnosed with early-onset preeclampsia (< 34 weeks' gestation), 14 with early-onset fetal growth restriction, and 25 gestation-matched controls. (2) Prospective cohort, collected at 36 weeks' gestation before diagnosis: 17 participants later developed preeclampsia, 49 delivered infants with fetal growth"],"journal":["Scientific reports"],"pubmed_title":["Plasma metabolites are altered before and after diagnosis of preeclampsia or fetal growth restriction."],"pmcid":["PMC11233654"],"funding_grant_id":["#1136418","#FT210100193","1159261","1136418"],"pubmed_authors":["Tong S","MacDonald TM","Bartho LA","Perkins AV","Walker SP","Nijagal B","Kaitu'u-Lino TJ","Hannan NJ","Pritchard N","McKeating DR"],"additional_accession":[]},"is_claimable":false,"name":"Plasma metabolites are altered before and after diagnosis of preeclampsia or fetal growth restriction.","description":"Metabolomics is the study of small molecules (metabolites), within cells, tissues and biofluids. Maternal metabolites can provide important insight into the health and development of both mother and fetus throughout pregnancy. This study assessed metabolic profiles in the maternal circulation prior to and at the time of diagnosis of preeclampsia and fetal growth restriction. Maternal plasma samples were collected from two independent cohorts: (1) Established disease cohort: 50 participants diagnosed with early-onset preeclampsia (< 34 weeks' gestation), 14 with early-onset fetal growth restriction, and 25 gestation-matched controls. (2) Prospective cohort, collected at 36 weeks' gestation before diagnosis: 17 participants later developed preeclampsia, 49 delivered infants with fetal growth","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-04T11:24:51.482Z","creation":"2025-04-04T11:24:51.482Z"},"accession":"S-EPMC11233654","cross_references":{"pubmed":["38982217"],"doi":["10.1038/s41598-024-65947-9"]}}