{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nanaware PP"],"funding":["NCCIH NIH HHS","NIA NIH HHS","NIAID NIH HHS","Cure Alzheimer's Fund","NIAMS NIH HHS","NIH"],"pagination":["114311"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11233987"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(6)"],"pubmed_abstract":["The lymphatic fluid is the conduit by which part of the tissue \"omics\" is transported to the draining lymph node for immunosurveillance. Following cannulation of the pre-nodal cervical and mesenteric afferent lymphatics, herein we investigate the lymph proteomic composition, uncovering that its composition varies according to the tissue of origin. Tissue specificity is also reflected in the dendritic cell-major histocompatibility complex class II-eluted immunopeptidome harvested from the cervical and mesenteric nodes. Following inflammatory disruption of the gut barrier, the lymph antigenic and inflammatory loads are analyzed in both mice and subjects with inflammatory bowel diseases. Gastrointestinal tissue damage reflects the lymph inflammatory and damage-associated molecular pattern sig"],"journal":["Cell reports"],"pubmed_title":["Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load."],"pmcid":["PMC11233987"],"funding_grant_id":["R01 AI146180","P50 AR080593","R01 AT011419","R01 AI127869","R01 AI134696","R21 AR081493","R01 AI137198","P01 AG031782","R01 AI169723","R01 AI170897","R01 AI143976","R01 AG067581","R01 AI153828"],"pubmed_authors":["Lyden D","Nanaware PP","Longman R","Santambrogio L","D'Alessandro A","Jacob B Geri","Shetty M","Wan X","Lichti CF","Mota I","Soni RK","Lu TT","Clement CC","Seltzer ES","Matei I","Dzieciatkowska M","Ng C","Stern LJ","Unanue ER","Khan ZN","Nagayama M","Gamboni F"],"additional_accession":[]},"is_claimable":false,"name":"Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load.","description":"The lymphatic fluid is the conduit by which part of the tissue \"omics\" is transported to the draining lymph node for immunosurveillance. Following cannulation of the pre-nodal cervical and mesenteric afferent lymphatics, herein we investigate the lymph proteomic composition, uncovering that its composition varies according to the tissue of origin. Tissue specificity is also reflected in the dendritic cell-major histocompatibility complex class II-eluted immunopeptidome harvested from the cervical and mesenteric nodes. Following inflammatory disruption of the gut barrier, the lymph antigenic and inflammatory loads are analyzed in both mice and subjects with inflammatory bowel diseases. Gastrointestinal tissue damage reflects the lymph inflammatory and damage-associated molecular pattern sig","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-19T01:06:51.638Z","creation":"2025-04-07T11:57:33.513Z"},"accession":"S-EPMC11233987","cross_references":{"pubmed":["38848214"],"doi":["10.1016/j.celrep.2024.114311"]}}