{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stamellou E"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft"],"pagination":["sfae131"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11234294"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(7)"],"pubmed_abstract":["<h4>Background</h4>Focal segmental glomerulosclerosis (FSGS) can lead to kidney failure in adults. This study examines the progression of FSGS in the German Chronic Kidney Disease (GCKD) cohort.<h4>Methods</h4>The GCKD study (<i>N</i> = 5217), a prospective cohort, included 159 patients with biopsy-confirmed FSGS recruited from 2010 to 2012. Baseline was defined as the first study visit. Adjudicated endpoints included a composite kidney endpoint (CKE), including an estimated glomerular filtration rate (eGFR) decrease >40%, eGFR <15 ml/min/1.73 m<sup>2</sup> or initiation of kidney replacement therapy and combined major adverse cardiovascular events (MACE), including non-fatal myocardial infarction or stroke and all-cause mortality. Associations between baseline demographics, laboratory dat"],"journal":["Clinical kidney journal"],"pubmed_title":["Long-term outcomes of adults with FSGS in the German Chronic Kidney Disease cohort."],"pmcid":["PMC11234294"],"funding_grant_id":["01ER 0819","01ER 0818","01ER 0821","01ER 0820","01ER 0804"],"pubmed_authors":["Schiffer M","Bauer B","Meder S","Eckardt KU","Schaeffner E","Weissensteiner H","Kronenberg F","Wanner C","Kotsis F","Saritas T","Bechtel-Walz W","Forer L","Floege J","Mitsch E","Schmidt-Ott K","Stamellou E","Schonherr S","Gronwald W","Kottgen A","Ekici AB","Hendry B","Kollerits B","Prokosch HU","Reis A","Beck A","Alberth-Schmidt U","Busch M","Raschenberger J","Barthlein B","Schultheiß UT","Theisen K","Baid-Agrawal S","Oefner P","Reinhard U","Mercer A","Becker S","Schmid M","Steiner A","Schneider MP","Kramann R","Zeier M","Nadal J","Wolf G","Walz G","Krane V","Aykac M","Sitter T","Moeller MJ","Meiselbach H","Sommerer C","Marschall S","GCKD study investigators","Weigel A"],"additional_accession":[]},"is_claimable":false,"name":"Long-term outcomes of adults with FSGS in the German Chronic Kidney Disease cohort.","description":"<h4>Background</h4>Focal segmental glomerulosclerosis (FSGS) can lead to kidney failure in adults. This study examines the progression of FSGS in the German Chronic Kidney Disease (GCKD) cohort.<h4>Methods</h4>The GCKD study (<i>N</i> = 5217), a prospective cohort, included 159 patients with biopsy-confirmed FSGS recruited from 2010 to 2012. Baseline was defined as the first study visit. Adjudicated endpoints included a composite kidney endpoint (CKE), including an estimated glomerular filtration rate (eGFR) decrease >40%, eGFR <15 ml/min/1.73 m<sup>2</sup> or initiation of kidney replacement therapy and combined major adverse cardiovascular events (MACE), including non-fatal myocardial infarction or stroke and all-cause mortality. Associations between baseline demographics, laboratory dat","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-19T01:06:21.433Z","creation":"2025-04-07T12:02:50.652Z"},"accession":"S-EPMC11234294","cross_references":{"pubmed":["38989280"],"doi":["10.1093/ckj/sfae131"]}}