biostudies-literatureStamellou EBundesministerium für Bildung und ForschungDeutsche Forschungsgemeinschaftsfae131https://www.ebi.ac.uk/biostudies/studies/S-EPMC11234294biostudies-literatureUnknown17(7)<h4>Background</h4>Focal segmental glomerulosclerosis (FSGS) can lead to kidney failure in adults. This study examines the progression of FSGS in the German Chronic Kidney Disease (GCKD) cohort.<h4>Methods</h4>The GCKD study (<i>N</i> = 5217), a prospective cohort, included 159 patients with biopsy-confirmed FSGS recruited from 2010 to 2012. Baseline was defined as the first study visit. Adjudicated endpoints included a composite kidney endpoint (CKE), including an estimated glomerular filtration rate (eGFR) decrease >40%, eGFR <15 ml/min/1.73 m² or initiation of kidney replacement therapy and combined major adverse cardiovascular events (MACE), including non-fatal myocardial infarction or stroke and all-cause mortality. Associations between baseline demographics, laboratory datClinical kidney journalLong-term outcomes of adults with FSGS in the German Chronic Kidney Disease cohort.PMC1123429401ER 081901ER 081801ER 082101ER 082001ER 0804Schiffer MBauer BMeder SEckardt KUSchaeffner EWeissensteiner HKronenberg FWanner CKotsis FSaritas TBechtel-Walz WForer LFloege JMitsch ESchmidt-Ott KStamellou ESchonherr SGronwald WKottgen AEkici ABHendry BKollerits BProkosch HUReis ABeck AAlberth-Schmidt UBusch MRaschenberger JBarthlein BSchultheiß UTTheisen KBaid-Agrawal SOefner PReinhard UMercer ABecker SSchmid MSteiner ASchneider MPKramann RZeier MNadal JWolf GWalz GKrane VAykac MSitter TMoeller MJMeiselbach HSommerer CMarschall SGCKD study investigatorsWeigel AfalseLong-term outcomes of adults with FSGS in the German Chronic Kidney Disease cohort.<h4>Background</h4>Focal segmental glomerulosclerosis (FSGS) can lead to kidney failure in adults. This study examines the progression of FSGS in the German Chronic Kidney Disease (GCKD) cohort.<h4>Methods</h4>The GCKD study (<i>N</i> = 5217), a prospective cohort, included 159 patients with biopsy-confirmed FSGS recruited from 2010 to 2012. Baseline was defined as the first study visit. Adjudicated endpoints included a composite kidney endpoint (CKE), including an estimated glomerular filtration rate (eGFR) decrease >40%, eGFR <15 ml/min/1.73 m² or initiation of kidney replacement therapy and combined major adverse cardiovascular events (MACE), including non-fatal myocardial infarction or stroke and all-cause mortality. Associations between baseline demographics, laboratory dat2024-01-01T00:00:00Z2024 Jul2025-04-19T01:06:21.433Z2025-04-07T12:02:50.652ZS-EPMC112342943898928010.1093/ckj/sfae131