{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan KN"],"funding":["Science and Technology Commission of Shanghai Municipality","Shanghai Institute of Materia Medica, Chinese Academy of Sciences","National Natural Science Foundation of China"],"pagination":["e2400594"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11234393"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(26)"],"pubmed_abstract":["Proteolysis targeting chimeras (PROTACs) have emerged as a promising strategy for drug discovery and exploring protein functions, offering a revolutionary therapeutic modality. Currently, the predominant approach to PROTACs discovery mainly relies on an empirical design-synthesis-evaluation process involving numerous cycles of labor-intensive synthesis-purification and bioassay data collection. Therefore, the development of innovative methods to expedite PROTAC synthesis and exploration of chemical space remains highly desired. Here, a direct-to-biology strategy is reported to streamline the synthesis of PROTAC libraries on plates, enabling the seamless transfer of reaction products to cell-based bioassays without the need for additional purification. By integrating amide coupling and ligh"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry."],"pmcid":["PMC11234393"],"funding_grant_id":["21S11900700","22377133","SIMM0220233001","22377136"],"pubmed_authors":["Yan KN","Hu H","Liu Q","Chen XH","Sun X","Wang JY","Nie YQ","Yin GL"],"additional_accession":[]},"is_claimable":false,"name":"Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry.","description":"Proteolysis targeting chimeras (PROTACs) have emerged as a promising strategy for drug discovery and exploring protein functions, offering a revolutionary therapeutic modality. Currently, the predominant approach to PROTACs discovery mainly relies on an empirical design-synthesis-evaluation process involving numerous cycles of labor-intensive synthesis-purification and bioassay data collection. Therefore, the development of innovative methods to expedite PROTAC synthesis and exploration of chemical space remains highly desired. Here, a direct-to-biology strategy is reported to streamline the synthesis of PROTAC libraries on plates, enabling the seamless transfer of reaction products to cell-based bioassays without the need for additional purification. By integrating amide coupling and ligh","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-05T15:48:50.947Z","creation":"2025-04-05T15:48:50.947Z"},"accession":"S-EPMC11234393","cross_references":{"pubmed":["38689503"],"doi":["10.1002/advs.202400594"]}}