biostudies-literatureZheng YShanghai Top Priority Research Center construction projectNational Natural Science Foundation59https://www.ebi.ac.uk/biostudies/studies/S-EPMC11234664biostudies-literatureUnknown22(1)<h4>Background</h4>Routine coagulation tests are not widely accepted diagnostic criteria of trauma-induced hypercoagulopathy (TIH) due to insensitivity. Lymphatic vessels drain approximately 10% of the interstitial fluid into the lymphatic system and form lymph.<h4>Subjective</h4>The purpose of this study was to identify the potential lymph biomarkers for TIH.<h4>Methods</h4>Eighteen male Sprague-Dawley rats were randomly assigned to the sham (non-fractured rats with sham surgery and vehicle treatment), the VEH (fractured rats with vehicle treatment) and the CLO (fractured rats with clopidogrel treatment) group. Thoracic duct lymph was obtained to perform proteomics and untargeted metabolomics.<h4>Results</h4>A total of 1207 proteins and 16,695 metabolites were identified. The top 5 GO terThrombosis journalIntegrated proteomic and metabolomic profiling of lymph after trauma-induced hypercoagulopathy and antithrombotic therapy.PMC11234664821744072022ZZ01009Zheng YWang PCong LShi QWang YZhao YfalseIntegrated proteomic and metabolomic profiling of lymph after trauma-induced hypercoagulopathy and antithrombotic therapy.<h4>Background</h4>Routine coagulation tests are not widely accepted diagnostic criteria of trauma-induced hypercoagulopathy (TIH) due to insensitivity. Lymphatic vessels drain approximately 10% of the interstitial fluid into the lymphatic system and form lymph.<h4>Subjective</h4>The purpose of this study was to identify the potential lymph biomarkers for TIH.<h4>Methods</h4>Eighteen male Sprague-Dawley rats were randomly assigned to the sham (non-fractured rats with sham surgery and vehicle treatment), the VEH (fractured rats with vehicle treatment) and the CLO (fractured rats with clopidogrel treatment) group. Thoracic duct lymph was obtained to perform proteomics and untargeted metabolomics.<h4>Results</h4>A total of 1207 proteins and 16,695 metabolites were identified. The top 5 GO ter2024-01-01T00:00:00Z2024 Jul2026-06-02T11:47:59.825Z2026-04-18T03:10:59.797ZS-EPMC112346643898779210.1186/s12959-024-00634-3