{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(1)"],"submitter":["Shao C"],"pubmed_abstract":["The lung is the respiratory organ of the human body, and the alveoli are the most basic functional units of the lung. Herein, a photo-responsive stretchable Janus membrane was proposed for the reconstruction of the alveolar-capillary barrier in vitro. This Janus membrane was fabricated by photocrosslinking methylacrylamide gelatin (Gelma) hydrogel and N-isoacrylamide (NIPAM) hydrogel mixed with graphene oxide (GO). The Gelma hydrogel containing large amounts of collagen provides a natural extracellular matrix environment for cell growth, while the temperature-sensitive NIPAM hydrogel combined with GO gives the membrane a light-controlled stretching property. Based on this Janus membrane, an open polydimethylsiloxane chip was established to coculture alveolar epithelial cells and vascular e"],"journal":["Smart medicine"],"pagination":["e20220035"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11235665"],"repository":["biostudies-literature"],"pubmed_title":["Reconstruction of the alveolar-capillary barrier in vitro based on a photo-responsive stretchable Janus membrane."],"pmcid":["PMC11235665"],"pubmed_authors":["Cao T","Wang X","Ye F","Fan Q","Shao C"],"additional_accession":[]},"is_claimable":false,"name":"Reconstruction of the alveolar-capillary barrier in vitro based on a photo-responsive stretchable Janus membrane.","description":"The lung is the respiratory organ of the human body, and the alveoli are the most basic functional units of the lung. Herein, a photo-responsive stretchable Janus membrane was proposed for the reconstruction of the alveolar-capillary barrier in vitro. This Janus membrane was fabricated by photocrosslinking methylacrylamide gelatin (Gelma) hydrogel and N-isoacrylamide (NIPAM) hydrogel mixed with graphene oxide (GO). The Gelma hydrogel containing large amounts of collagen provides a natural extracellular matrix environment for cell growth, while the temperature-sensitive NIPAM hydrogel combined with GO gives the membrane a light-controlled stretching property. Based on this Janus membrane, an open polydimethylsiloxane chip was established to coculture alveolar epithelial cells and vascular e","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-19T19:41:58.812Z","creation":"2025-04-19T19:41:58.812Z"},"accession":"S-EPMC11235665","cross_references":{"pubmed":["39188563"],"doi":["10.1002/SMMD.20220035"]}}