biostudies-literaturePeyre MFrench CRCFrench national PHRCe16211https://www.ebi.ac.uk/biostudies/studies/S-EPMC11235986biostudies-literatureUnknown31(5)<h4>Background</h4>Nonreversible hearing loss (HL) is the main sequelae of Susac syndrome (SuS). We aimed to identify risk factors for HL in SuS.<h4>Methods</h4>The CARESS study is a prospective national cohort study that started in December 2011, including all consecutive patients with SuS referred to the French reference center. The CARESS study was designed with a follow-up including fundoscopy, audiometry, and brain magnetic resonance imaging at 1, 3, 6, and 12 months after diagnosis and then annually for 5 years. The primary outcome was the occurrence at last follow-up of severe HL defined as the loss of 70 dB in at least one ear on audiometry or the need for hearing aids.<h4>Results</h4>Thirty-six patients (female 66.7%, median age 37.5 [range 24.5-42.5] years) included in the clinicEuropean journal of neurologyRisk factors for severe hearing loss in Susac syndrome: A national cohort study.PMC11235986P081261CRC19059Sacre KFrench Susac Study GroupHalimi CTurc GDebruxelles SPapo TCapron JPeyre MLapergue BMageau AMohamed SRouzaud Dde Brouker THenry Feugeas MCDoan SHamidou MLaouenan CFrancois CDelory NGodard-Ducceschi SGrosset-Janin DLe Quellec AMouthon LChauveheid MPGoulenok TNoury JBBeldjoudi NKlein IAlexandra JFFarhi FBodenant MGodeau BAumaitre OWacongne Ade Bustos EMEllie EDossier AfalseRisk factors for severe hearing loss in Susac syndrome: A national cohort study.<h4>Background</h4>Nonreversible hearing loss (HL) is the main sequelae of Susac syndrome (SuS). We aimed to identify risk factors for HL in SuS.<h4>Methods</h4>The CARESS study is a prospective national cohort study that started in December 2011, including all consecutive patients with SuS referred to the French reference center. The CARESS study was designed with a follow-up including fundoscopy, audiometry, and brain magnetic resonance imaging at 1, 3, 6, and 12 months after diagnosis and then annually for 5 years. The primary outcome was the occurrence at last follow-up of severe HL defined as the loss of 70 dB in at least one ear on audiometry or the need for hearing aids.<h4>Results</h4>Thirty-six patients (female 66.7%, median age 37.5 [range 24.5-42.5] years) included in the clinic2024-01-01T00:00:00Z2024 May2026-06-02T22:12:52.301Z2025-04-19T13:13:44.93ZS-EPMC112359863823595510.1111/ene.16211