{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["631(8020)"],"submitter":["Jiang Y"],"pubmed_abstract":["Naturally occurring (native) sugars and carbohydrates contain numerous hydroxyl groups of similar reactivity<sup>1,2</sup>. Chemists, therefore, rely typically on laborious, multi-step protecting-group strategies<sup>3</sup> to convert these renewable feedstocks into reagents (glycosyl donors) to make glycans. The direct transformation of native sugars to complex saccharides remains a notable challenge. Here we describe a photoinduced approach to achieve site- and stereoselective chemical glycosylation from widely available native sugar building blocks, which through homolytic (one-electron) chemistry bypasses unnecessary hydroxyl group masking and manipulation. This process is reminiscent of nature in its regiocontrolled generation of a transient glycosyl donor, followed by radical-based "],"journal":["Nature"],"pagination":["319-327"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11236704"],"repository":["biostudies-literature"],"pubmed_title":["Direct radical functionalization of native sugars."],"pmcid":["PMC11236704"],"pubmed_authors":["Jiang Y","Song N","Levin N","Mohammed S","Zhang Y","Davis BG","Fu XP","Sun GQ","Wei Y","Zhou QY","Koh MJ","Liu WQ"],"additional_accession":[]},"is_claimable":false,"name":"Direct radical functionalization of native sugars.","description":"Naturally occurring (native) sugars and carbohydrates contain numerous hydroxyl groups of similar reactivity<sup>1,2</sup>. Chemists, therefore, rely typically on laborious, multi-step protecting-group strategies<sup>3</sup> to convert these renewable feedstocks into reagents (glycosyl donors) to make glycans. The direct transformation of native sugars to complex saccharides remains a notable challenge. Here we describe a photoinduced approach to achieve site- and stereoselective chemical glycosylation from widely available native sugar building blocks, which through homolytic (one-electron) chemistry bypasses unnecessary hydroxyl group masking and manipulation. This process is reminiscent of nature in its regiocontrolled generation of a transient glycosyl donor, followed by radical-based ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-05T15:49:02.648Z","creation":"2025-04-05T15:49:02.648Z"},"accession":"S-EPMC11236704","cross_references":{"pubmed":["38898275"],"doi":["10.1038/s41586-024-07548-0"]}}