{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Chen Y"],"pubmed_abstract":["Chronic liver disease, a long-term condition resulting from various causes such as alcohol abuse, metabolic disorders, and viral hepatitis, is becoming a significant global health challenge. Gypenosides (GPs), derived from the traditional Chinese medicine <i>Gynostemma pentaphyllum</i> (Thunb.) Makino, exhibited hepatoprotective properties in recent years, yet the precise therapeutic mechanism remains unclear. In this study, label-free and parallel reaction monitoring (PRM) proteomics were used to elucidate the hepatoprotective mechanism of GPs in liver injury rats. Through label-free proteomics, we identified 2104 differentially expressed proteins (DEPs) associated with liver injury, along with 1974 DEPs related to the effects of GPs. Bioinformatics analysis revealed that GPs primarily re"],"journal":["Frontiers in pharmacology"],"pagination":["1417575"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11236725"],"repository":["biostudies-literature"],"pubmed_title":["Label-free proteomic analysis reveals the hepatoprotective mechanism of gypenosides in liver injury rats."],"pmcid":["PMC11236725"],"pubmed_authors":["Wang M","Ma L","Zhang J","Chen Y","Wang Y","Pei T"],"additional_accession":[]},"is_claimable":false,"name":"Label-free proteomic analysis reveals the hepatoprotective mechanism of gypenosides in liver injury rats.","description":"Chronic liver disease, a long-term condition resulting from various causes such as alcohol abuse, metabolic disorders, and viral hepatitis, is becoming a significant global health challenge. Gypenosides (GPs), derived from the traditional Chinese medicine <i>Gynostemma pentaphyllum</i> (Thunb.) Makino, exhibited hepatoprotective properties in recent years, yet the precise therapeutic mechanism remains unclear. In this study, label-free and parallel reaction monitoring (PRM) proteomics were used to elucidate the hepatoprotective mechanism of GPs in liver injury rats. Through label-free proteomics, we identified 2104 differentially expressed proteins (DEPs) associated with liver injury, along with 1974 DEPs related to the effects of GPs. Bioinformatics analysis revealed that GPs primarily re","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T07:34:54.887Z","creation":"2025-04-07T12:03:06.726Z"},"accession":"S-EPMC11236725","cross_references":{"pubmed":["38994199"],"doi":["10.3389/fphar.2024.1417575"]}}