biostudies-literatureKhalil MNCI NIH HHS5283-5292https://www.ebi.ac.uk/biostudies/studies/S-EPMC11236845biostudies-literatureUnknown31(8)<h4>Background</h4>New persistent opioid use (NPOU) after surgery has been identified as a common complication. This study sought to assess the long-term health outcomes among patients who experienced NPOU after gastrointestinal (GI) cancer surgery.<h4>Methods</h4>Patients who underwent surgery for hepato-pancreato-biliary and colorectal cancer between 2007 and 2019 were identified using the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database. Mixed-effect multivariable logistic regression and Cox proportional hazard models were used to estimate the risk of mortality and hospital visits related to falls, respiratory events, or pain symptoms.<h4>Results</h4>Among 15,456 patients who underwent GI cancer surgery, 967(6.6%) experienced NPOU. Notably, the patients at risAnnals of surgical oncologyLong-term Health Outcomes of New Persistent Opioid Use After Gastrointestinal Cancer Surgery.PMC11236845HHSN261201800032IHHSN261201800009CHHSN261201800009IHHSN261201800015CHHSN261201800032CHHSN261201800015IKhalil MWoldesenbet SKhan MMMTsai SMunir MMEndo YRashid ZDillhoff MAltaf AKatayama EPawlik TMfalseLong-term Health Outcomes of New Persistent Opioid Use After Gastrointestinal Cancer Surgery.<h4>Background</h4>New persistent opioid use (NPOU) after surgery has been identified as a common complication. This study sought to assess the long-term health outcomes among patients who experienced NPOU after gastrointestinal (GI) cancer surgery.<h4>Methods</h4>Patients who underwent surgery for hepato-pancreato-biliary and colorectal cancer between 2007 and 2019 were identified using the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database. Mixed-effect multivariable logistic regression and Cox proportional hazard models were used to estimate the risk of mortality and hospital visits related to falls, respiratory events, or pain symptoms.<h4>Results</h4>Among 15,456 patients who underwent GI cancer surgery, 967(6.6%) experienced NPOU. Notably, the patients at ris2024-01-01T00:00:00Z2024 Aug2025-04-19T01:04:27.866Z2025-04-07T12:02:35.154ZS-EPMC112368453876264110.1245/s10434-024-15435-1